Gold Nanoclusters-Based NIR-II Photosensitizers with Catalase-like Activity for Boosted Photodynamic Therapy.
Gold Nanoclusters-Based NIR-II Photosensitizers with Catalase-like Activity for Boosted Photodynamic Therapy.
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基于金纳米团簇的 NIR-II 光敏剂，具有类似过氧化氢酶的活性，可增强光动力治疗
DOI：
10.3390/pharmaceutics14081645
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发表时间：
2022-08-07
期刊：
影响因子：
5.4
通讯作者：
Li, Yingjia
中科院分区：
文献类型：
--
作者：
Dan, Qing;Yuan, Zhen;Zheng, Si;Ma, Huanrong;Luo, Wanxian;Zhang, Li;Su, Ning;Hu, Dehong;Sheng, Zonghai;Li, Yingjia
荧光成像下的光动力疗法（PDT）作为一种选择性、非侵入性的治疗方法，已广泛应用于癌症和细菌感染的治疗。然而，其处理效率受到第一近红外窗口（NIR-I，700-900 nm）中的高背景荧光和传统光敏剂的氧依赖性光敏活性的阻碍。在这项工作中，我们采用具有第二近红外（NIR-II，1000-1700 nm）荧光和过氧化氢酶样活性的金纳米团簇（BSA@Au）作为替代光敏剂来实现高效的PDT。BSA@Au的明亮的NIR-II荧光使得能够在4 T1荷瘤小鼠模型中以高信号背景比（SBR = 7.3）可视化肿瘤的PDT。此外，BSA@Au的过氧化氢酶样活性赋予其氧气自我供应能力，与对照组相比，接受加强PDT治疗的荷瘤小鼠的存活期增加了5倍。此外，我们进一步证明了基于BSA@ Au的PDT策略可以应用于治疗细菌感染。我们的研究显示了NIR-II BSA@Au作为一种新型光敏剂用于增强PDT对抗癌症和细菌感染的巨大潜力。
Photodynamic therapy (PDT) under fluorescence imaging as a selective and non-invasive treatment approach has been widely applied for the therapy of cancer and bacterial infections. However, its treatment efficiency is hampered by high background fluorescence in the first near-infrared window (NIR-I, 700–900 nm) and oxygen-dependent photosensitizing activity of traditional photosensitizers. In this work, we employ gold nanoclusters (BSA@Au) with the second near-infrared (NIR-II, 1000–1700 nm) fluorescence and catalase-like activity as alternative photosensitizers to realize highly efficient PDT. The bright NIR-II fluorescence of BSA@Au enables the visualization of PDT for tumor with a high signal-to-background ratio (SBR = 7.3) in 4T1 tumor-bearing mouse models. Furthermore, the catalase-like activity of BSA@Au endows its oxygen self-supplied capability, contributing to a five-fold increase in the survival period of tumor-bearing mice receiving boosted PDT treatment compared to that of the control group. Moreover, we further demonstrate that BSA@Au-based PDT strategy can be applied to treat bacterial infections. Our studies show the great potential of NIR-II BSA@Au as a novel photosensitizer for boosted PDT against cancer and bacterial infections.
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影响因子：
15
作者：
Murphy, JE;Beard, MC;Nozik, AJ
通讯作者：
Nozik, AJ
具有改进的发光和生物命运的近红外 II 金纳米团簇组件，用于 H(2)S 体内比例成像。
影响因子：
7.4
作者：
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通讯作者：
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DOI：
10.1016/j.msec.2020.110891
发表时间：
2020-07-01
影响因子：
7.9
作者：
Lillo, Cristian R.;Calienni, M. Natalia;Soler-Illia, Galo J. A. A.
通讯作者：
Soler-Illia, Galo J. A. A.
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影响因子：
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作者：
Ge, Jiechao;Lan, Minhuan;Zhou, Bingjiang;Liu, Weimin;Guo, Liang;Wang, Hui;Jia, Qingyan;Niu, Guangle;Huang, Xing;Zhou, Hangyue;Meng, Xiangmin;Wang, Pengfei;Lee, Chun-Sing;Zhang, Wenjun;Han, Xiaodong
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Han, Xiaodong
影响因子：
24.2
作者：
Kong, Yifei;Santos-Carballal, David;Wu, Mei X.
通讯作者：
Wu, Mei X.