Mechanisms Underlying Poststimulation Block Induced by High-Frequency Biphasic Stimulation.
Mechanisms Underlying Poststimulation Block Induced by High-Frequency Biphasic Stimulation.
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DOI：
10.1111/ner.13501
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发表时间：
2023-04
期刊：
影响因子：
--
通讯作者：
Tai C
中科院分区：
文献类型：
--
作者：
Zhong Y;Wang J;Beckel J;de Groat WC;Tai C
目的：揭示高频双相刺激(HFBS)引起刺激后阻滞的可能机制。建立了一种新的无髓鞘轴突传导模型。这个新模型不同于经典的轴突传导模型，它同时包括离子浓度和膜离子泵，以允许分析轴突对长时间刺激的反应。利用新的模型，对动物实验中报道的HFBS后阻断现象在广泛的刺激频率范围(100 Hz-10 kHz)下进行了模拟和分析。HFBS可以显著改变轴突内外的Na+和K+浓度，根据HFBS的持续时间，产生短期(<；500ms)或长期(>；3秒)的HFBS后阻断。持续时间较短的阻滞是由于离子扩散进入和离开大的细胞外间隙，使轴突周围间隙内Na+和K+浓度迅速恢复，而持续时间较长的阻滞是由于膜离子泵使轴突内正常的Na+浓度缓慢恢复所致。100 HzHFBS需要最小的电能来实现HFBS后的阻断，而10 kHz刺激是实现HFBS后阻断所需的最低有效频率，需要高强度和长时间。这项研究揭示了HFBS后阻断轴突传导的两种可能的离子机制。了解这些机制对于改善HFBS的临床应用和开发新的使用HFBS的神经阻滞方法具有重要意义。
To reveal the possible mechanisms underlying post-stimulation block induced by high frequency biphasic stimulation (HFBS). A new axonal conduction model is developed for unmyelinated axons. This new model is different from the classical axonal conduction model by including both ion concentrations and membrane ion pumps to allow analysis of axonal responses to long-duration stimulation. Using the new model, the post-HFBS block phenomenon reported in animal studies is simulated and analyzed for a wide range of stimulation frequencies (100 Hz – 10 kHz). HFBS can significantly change the Na+ and K+ concentrations inside and outside the axon to produce a post-HFBS block of either short-duration (<500 ms) or long-duration (>3 seconds) depending on the duration of HFBS. The short-duration block is due to the fast recovery of the Na+ and K+ concentrations outside the axon in periaxonal space by diffusion of ions into and from the large extracellular space, while the long-duration block is due to the slow restoration of the normal Na+ concentration inside the axon by membrane ion pumps. The 100 Hz HFBS requires the minimal electrical energy to achieve the post-HFBS block, while the 10 kHz stimulation is the least effective frequency requiring high intensity and long duration to achieve the block. This study reveals two possible ionic mechanisms underlying post-HFBS block of axonal conduction. Understanding these mechanisms is important for improving clinical applications of HFBS block and for developing new nerve block methods employing HFBS.
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DOI：
10.1111/ner.13241
发表时间：
2021-08
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Shapiro K;Guo W;Armann K;Pace N;Shen B;Wang J;Beckel J;de Groat W;Tai C
通讯作者：
Tai C
影响因子：
4
作者：
Ackermann DM;Bhadra N;Gerges M;Thomas PJ
通讯作者：
Thomas PJ
影响因子：
2.8
作者：
Soin, Amol;Shah, Nemath Syed;Fang, Zi-Ping
通讯作者：
Fang, Zi-Ping
影响因子：
4
作者：
Bhadra N;Foldes E;Vrabec T;Kilgore K;Bhadra N
通讯作者：
Bhadra N
影响因子：
3.2
作者：
Yang, Guangning;Xiao, Zhiying;Wang, Jicheng;Shen, Bing;Roppolo, James R.;de Groat, William C.;Tai, Changfeng
通讯作者：
Tai, Changfeng