Post-stimulation block of frog sciatic nerve by high-frequency (kHz) biphasic stimulation.
Post-stimulation block of frog sciatic nerve by high-frequency (kHz) biphasic stimulation.
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DOI：
10.1007/s11517-016-1539-0
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发表时间：
2017-04
影响因子：
3.2
通讯作者：
Tai, Changfeng
中科院分区：
文献类型：
--
作者：
Yang, Guangning;Xiao, Zhiying;Wang, Jicheng;Shen, Bing;Roppolo, James R.;de Groat, William C.;Tai, Changfeng
本研究确定高频双相刺激是否可以引起刺激终止后持续存在的神经传导阻滞，即刺激后阻滞。该研究中使用了青蛙坐骨神经肌肉制剂。记录低频（0.5 Hz）神经刺激引起的肌肉收缩力，以指示高频（5或10 kHz）双相刺激引起的神经阻滞的发生和恢复。在高频刺激期间和刺激终止后观察到神经阻滞。刺激后阻滞的恢复发生在两个不同的阶段。在第一阶段，维持高频刺激期间诱导的完全阻滞。第一阶段的平均最大持续时间为 107±50 秒。在第二阶段，区块逐渐或突然逆转。第一阶段和第二阶段的持续时间取决于刺激强度和持续时间，而不是频率。较高强度（1.4-2 倍阻滞阈值）和较长持续时间（5 分钟）的刺激可产生最长的完全恢复时间（249±58 秒）。高频双相刺激可以引起刺激后阻滞，这对于未来阻滞机制的研究以及临床应用中刺激参数或方案的优化非常重要。
This study determined if high-frequency biphasic stimulation can induce nerve conduction block that persists after the stimulation is terminated, i.e. post-stimulation block. The frog sciatic nerve-muscle preparation was used in the study. Muscle contraction force induced by low frequency (0.5 Hz) nerve stimulation was recorded to indicate the occurrence and recovery of nerve block induced by the high-frequency (5 or 10 kHz) biphasic stimulation. Nerve block was observed during high-frequency stimulation and after termination of the stimulation. The recovery from post-stimulation block occurred in two distinct phases. During the first phase, the complete block induced during high-frequency stimulation was maintained. The average maximal duration for the first phase was 107±50 seconds. During the second phase, the block gradually or abruptly reversed. The duration of both first and second phases was dependent on stimulation intensity and duration but not frequency. Stimulation of higher intensity (1.4–2 times block threshold) and longer duration (5 minutes) produced the longest period (249±58 seconds) for a complete recovery. Post-stimulation block can be induced by high-frequency biphasic stimulation, which is important for future investigations of the blocking mechanisms and for optimizing the stimulation parameters or protocols in clinical applications.
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DOI：
10.1111/ner.12100
发表时间：
2014-04
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Kilgore KL;Bhadra N
通讯作者：
Bhadra N
影响因子：
2.9
作者：
Sarr, Michael G.;Billington, Charles J.;Rosenthal, Raul
通讯作者：
Rosenthal, Raul
影响因子：
2.8
作者：
Soin, Amol;Shah, Nemath Syed;Fang, Zi-Ping
通讯作者：
Fang, Zi-Ping
影响因子：
3.4
作者：
Bhadra, N;Kilgore, KL
通讯作者：
Kilgore, KL
影响因子：
4
作者：
Liu, Hailong;Zhu, Linlin;Qiu, Tianshuang
通讯作者：
Qiu, Tianshuang