Temporary persistence of conduction block after prolonged kilohertz frequency alternating current on rat sciatic nerve.
Temporary persistence of conduction block after prolonged kilohertz frequency alternating current on rat sciatic nerve.
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DOI：
10.1088/1741-2552/aa89a4
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发表时间：
2018-01-08
影响因子：
4
通讯作者：
Bhadra N
中科院分区：
文献类型：
--
作者：
Bhadra N;Foldes E;Vrabec T;Kilgore K;Bhadra N
应用千赫兹频率交流电（KHFAC）波形可导致在不到一秒的时间内诱发神经传导阻滞。当施加KHFAC约5 - 10分钟时，传导在几秒钟内恢复。本研究采用双极铂电极观察了KHFAC对大鼠坐骨神经的作用。研究了KHFAC在信号幅度下的不同持续时间对传导阻滞的影响。通过使用阻断电极近端（PS）和远端（DS）的刺激电极记录腓肠肌肌力峰值来监测神经传导。PS信号穿过神经上的阻滞区，而DS信号直接到达运动终板连接处。PS/DS力比提供了阻滞区神经传导通畅性的测量。传导恢复时间被认为是显着影响KHFAC应用程序的累积持续时间。当施加KHFAC少于约15分钟时，在停止KHFAC递送后，峰值刺激的肌肉力量立即恢复到阻断前的水平。对于测试的开/关时间和频率，它们显著下降，但在50 +/-20分钟之间的累积刺激下恢复到接近阻滞前的水平。传导分两个阶段恢复，最初的快速阶段（60-80%恢复），随后是较慢的阶段。在任何实验中，观察期结束时均未观察到永久性传导阻滞。这种传导阻滞效应（COBE）可用于在不连续应用KHFAC的情况下提供周围神经的连续传导阻滞。
Application of Kilohertz Frequency Alternating Current (KHFAC) waveforms can result in nerve conduction block that is induced in less than a second. Conduction recovers within seconds when KHFAC is applied for about 5 – 10 minutes. This study investigated the effect of repeated and prolonged application of KHFAC on rat Sciatic nerve with bipolar platinum electrodes. Varying durations of KHFAC at signal amplitudes for conduction block with intervals of no stimulus were studied. Nerve conduction was monitored by recording peak Gastrocnemius muscle force utilizing stimulation electrodes proximal (PS) and distal (DS) to a blocking electrode. The PS signal traveled through the block zone on the nerve, while the DS went directly to the motor end-plate junction. The PS/DS force ratio provided a measure of conduction patency of the nerve in the block zone. Conduction recovery times were found to be significantly affected by the cumulative duration of KHFAC application. Peak stimulated muscle force returned to pre-block levels immediately after cessation of KHFAC delivery when it was applied for less than about 15 minutes. They fell significantly but recovered to near pre-block levels for cumulative stimulus between 50 +/− 20 minutes, for the tested On / Off times and frequencies. Conduction recovered in two phases, an initial fast one (60–80% recovery), followed by a slower phase. No permanent conduction block was seen at the end of the observation period during any experiment. This Carry-over Block Effect (COBE) may be exploited to provide continuous conduction block in peripheral nerves without continuous application of KHFAC.
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DOI：
10.1111/ner.12100
发表时间：
2014-04
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Kilgore KL;Bhadra N
通讯作者：
Bhadra N
影响因子：
3
作者：
Franke, Manfred;Bhadra, Niloy;Bhadra, Narendra;Kilgore, Kevin
通讯作者：
Kilgore, Kevin
影响因子：
3
作者：
Foldes, Emily L.;Ackermann, D. Michael;Bhadra, Niloy;Kilgore, Kevin L.;Bhadra, Narendra
通讯作者：
Bhadra, Narendra
影响因子：
3.4
作者：
Bhadra, N;Kilgore, KL
通讯作者：
Kilgore, KL
影响因子：
4
作者：
Liu, Hailong;Zhu, Linlin;Qiu, Tianshuang
通讯作者：
Qiu, Tianshuang