Effects of 5-hydroxytryptamine 2C receptor agonist MK212 and 2A receptor antagonist MDL100907 on maternal behavior in postpartum female rats.
Effects of 5-hydroxytryptamine 2C receptor agonist MK212 and 2A receptor antagonist MDL100907 on maternal behavior in postpartum female rats.
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5-羟色胺2C受体激动剂MK212和2A受体拮抗剂MDL100907对产后雌性大鼠母性行为的影响。
DOI：
10.1016/j.pbb.2013.11.034
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发表时间：
2014-02
影响因子：
3.6
通讯作者：
Li, Ming
中科院分区：
文献类型：
--
作者：
Chen, Weihai;Zhang, Qi;Su, Wenxin;Zhang, Haorong;Yang, Yu;Qiao, Jing;Sui, Nan;Li, Ming
大鼠的母性行为是一种高度动机性和组织性的社会行为。鉴于5-羟色胺（5-HT）在情绪、动机、社会行为和重度抑郁症中的已知作用，以及它与多巴胺的已知相互作用，5-羟色胺很可能在这种行为中也起着至关重要的作用。到目前为止，除了母亲的攻击行为外，很少有研究关注5-HT在母亲行为中的作用。在本研究中，我们研究了5-HT 2C受体激动剂和5-HT 2A受体拮抗剂对产后雌性大鼠母性行为的影响。我们假设5-HT 2C受体的激活和5-HT 2A受体的阻断会产生功能上等同的母性行为中断，因为这两种受体亚型通常对与大鼠母性行为相关的各种脑功能和心理过程产生相反的影响。在产后第5、7和9天，Sprague-Dawley母大鼠单次注射0.9%NaCl溶液、5-HT 2C激动剂MK212（0.5、1.0或2.0 mg/kg，ip）或5-HT 2A拮抗剂MDL 100907（0.05、0.5或2.0 mg/kg，ip）。分别于注射前30 min、注射后30 min、120 min、240 min进行母性行为测试。急性注射MK212以剂量依赖性方式显著破坏了幼犬的取回、幼犬的舔舔、幼犬的护理和筑巢。在试验剂量下，MDL 100907对大鼠母性行为的各个组成部分几乎没有影响。在3天的试验中，没有发现与MK212和MDL 100907重复给药相关的明显致敏或耐受性。我们得出结论，大鼠母体性能严重依赖于5-HT 2C受体，而5-HT 2A受体的作用仍不确定。本文还讨论了5-HT_2C受体在母性行为中可能的作用机制。
Maternal behavior in rats is a highly motivated and well-organized social behavior. Given the known roles of serotonin (5-HT) in emotion, motivation, social behavior, and major depression - and its known interaction with dopamine - it is likely that serotonin also plays a crucial role in this behavior. So far, there are surprisingly few studies focusing on 5-HT in maternal behavior, except for maternal aggression. In the present study, we examined the effects of 5-HT2C receptor agonism and 5-HT2A receptor antagonism on maternal behavior in postpartum female rats. We hypothesized that activation of 5-HT2C receptors and blockade of 5-HT2A receptors would produce a functionally equivalent disruption of maternal behavior because these two receptor subtypes often exert opposite effects on various brain functions and psychological processes relevant to rat maternal behavior. On postpartum Days 5, 7, and 9, Sprague-Dawley mother rats were given a single injection of 0.9% NaCl solution, the 5-HT2C agonist MK212 (0.5, 1.0 or 2.0 mg/kg, ip), or the 5-HT2A antagonist MDL100907 (0.05, 0.5 or 2.0 mg/kg, ip). Maternal behavior was tested 30 min before and 30 min, 120 min, 240 min after injection. Acute injection of MK212 significantly disrupted pup retrieval, pup licking, pup nursing, and nest building in a dose-dependent fashion. At the tested doses, MDL100907 had little effect on various components of rat maternal behavior. Across the 3 days of testing, no apparent sensitization or tolerance associated with repeated administration of MK212 and MDL100907 was found. We concluded that rat maternal performance is critically dependent on 5-HT2C receptors, while the role of 5-HT2A receptors is still inconclusive. Possible behavioral mechanisms of actions of 5-HT2C receptor in maternal behavior are discussed.
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影响因子：
3.7
作者：
Bubar MJ;Stutz SJ;Cunningham KA
通讯作者：
Cunningham KA
影响因子：
3.4
作者：
Cruz, APM;Pinheiro, G;Landeira-Fernandez, J
通讯作者：
Landeira-Fernandez, J
DOI：
10.1073/pnas.0810793106
发表时间：
2009-06-23
影响因子：
11.1
作者：
Alenina, Natalia;Kikic, Dana;Bader, Michael
通讯作者：
Bader, Michael
影响因子：
3.6
作者：
Di Matteo, V;Cacchio, M;Esposito, E
通讯作者：
Esposito, E
影响因子：
2.9
作者：
Febo, Marcelo;Felix-Ortiz, Ada C.;Johnson, Tehya R.
通讯作者：
Johnson, Tehya R.