Inactivation or inhibition of neuronal activity in the medial prefrontal cortex largely reduces pup retrieval and grouping in maternal rats.
Inactivation or inhibition of neuronal activity in the medial prefrontal cortex largely reduces pup retrieval and grouping in maternal rats.
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DOI：
10.1016/j.brainres.2010.02.027
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发表时间：
2010-04-14
期刊：
影响因子：
2.9
通讯作者：
Johnson, Tehya R.
中科院分区：
文献类型：
--
作者：
Febo, Marcelo;Felix-Ortiz, Ada C.;Johnson, Tehya R.
关键词：
先前的研究表明，母亲的内侧前额叶皮质（mPFC）可能在母亲的护理中发挥作用，怀孕前的可卡因致敏会影响该区域内的神经元活动。目前的工作是进行测试是否mPFC实际上发挥作用，在大鼠的母性行为的表达，并了解什么样的具体行为，这个皮质区可能调制。在第一个实验中，河豚毒素（TTX）被用来化学染色的mPFC在测试的母亲的行为lastness。在产后第7-9天对哺乳期大鼠进行测试。第一个实验的结果表明，TTX诱导的失活对提取行为延迟有很大的影响。TTX几乎取消了表达的母鼠检索没有显着损害自发活动。在第二个实验中，使用GABA介导的抑制来测试产后母鼠的母性行为延迟以及母性行为和其他行为的持续时间。与实验1一致，据观察，大坝能够检索无法在mPFC的抑制。GABA介导的mPFC抑制在很大程度上减少了检索，而不改变其他指标的孕产妇护理和非特异性行为，如amabeling时间，自我梳理，和不活动。此外，在这两个实验中，母鼠都能在几秒钟内与幼崽建立联系。总体结果表明，mPFC可能发挥积极的作用，在调制产妇护理，特别是检索行为。影响额叶皮质功能的外部因素可能会导致母亲目标导向行为的显著损害，正如我们早期的工作所报道的那样。
Previous research suggests that the maternal medial prefrontal cortex (mPFC) may play a role in maternal care and that cocaine sensitization before pregnancy can affect neuronal activity within this region. The present work was carried out to test whether the mPFC does actually play a role in the expression of maternal behaviors in the rats and to understand what specific behaviors this cortical area may modulate. In the first experiment, tetrodotoxin (TTX) was used to chemically inactivate the mPFC during tests for maternal behavior latencies. Lactating rats were tested on postpartum day 7–9. The results of this first experiment indicate that there is a large effect of TTX-induced inactivation on retrieval behavior latencies. TTX nearly abolished the expression of maternal retrieval of pups without significantly impairing locomotor activity. In the second experiment, GABA-mediated inhibition was used to test maternal behavior latencies and durations of maternal and other behaviors in postpartum dams. In agreement with experiment 1, it was observed that dams capable of retrieving are rendered incapable by inhibition in the mPFC. GABA-mediated inhibition in the mPFC largely reduced retrieval without altering other indices of maternal care and non-specific behavior such as ambulation time, self-grooming, and inactivity. Moreover, in both experiments dams were able to establish contact with pups within seconds. The overall results indicate that the mPFC may play an active role in modulating maternal care, particularly retrieval behavior. External factors that affect the function of the frontal cortical site may result in significant impairments in maternal goal-directed behavior as reported in our earlier work.
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