Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities.
Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities.
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DOI：
10.1038/s41598-022-27252-1
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发表时间：
2023-01-18
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
心血管衰老会导致认知障碍。然而，多种心血管因素对认知功能的独特和协同作用仍不清楚，因为它们通常被浓缩为单个综合评分或单独检查。我们假设血管危险因素、心电图特征和血压指数揭示了多种潜在的血管因素，对认知具有独立的贡献。在一项基于人群的深度表型研究（n = 708，年龄 18-88）中，路径分析揭示了三个潜在的血管因素，将自主神经系统反应与血压的两个组成部分分开。这三个因素对结晶智力和流体智力的变异性做出了独特且附加的贡献。液体相对于结晶智力的差异表明认知能力下降，与主要表达脉压的潜在血管因素有关。这表明较高的脉压与预期表现的认知能力下降有关。这种效应在老年人中更为明显。控制脉压可能有助于保持认知能力，尤其是老年人。我们的研究结果强调需要更好地了解血管老化的多因素性质。
Cardiovascular ageing contributes to cognitive impairment. However, the unique and synergistic contributions of multiple cardiovascular factors to cognitive function remain unclear because they are often condensed into a single composite score or examined in isolation. We hypothesized that vascular risk factors, electrocardiographic features and blood pressure indices reveal multiple latent vascular factors, with independent contributions to cognition. In a population-based deep-phenotyping study (n = 708, age 18–88), path analysis revealed three latent vascular factors dissociating the autonomic nervous system response from two components of blood pressure. These three factors made unique and additive contributions to the variability in crystallized and fluid intelligence. The discrepancy in fluid relative to crystallized intelligence, indicative of cognitive decline, was associated with a latent vascular factor predominantly expressing pulse pressure. This suggests that higher pulse pressure is associated with cognitive decline from expected performance. The effect was stronger in older adults. Controlling pulse pressure may help to preserve cognition, particularly in older adults. Our findings highlight the need to better understand the multifactorial nature of vascular aging.
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DOI：
10.1016/j.dadm.2017.05.007
发表时间：
2017
期刊：
Alzheimer's & dementia (Amsterdam, Netherlands)
影响因子：
--
作者：
Albanese E;Launer LJ;Egger M;Prince MJ;Giannakopoulos P;Wolters FJ;Egan K
通讯作者：
Egan K
影响因子：
3
作者：
Harrington, Karra D.;Dang, Christa;Maruff, Paul
通讯作者：
Maruff, Paul
影响因子：
4.9
作者：
CATTELL, RB
通讯作者：
CATTELL, RB
影响因子：
3.3
作者：
Harada CN;Natelson Love MC;Triebel KL
通讯作者：
Triebel KL
影响因子：
2.3
作者：
Bajpai, Swati;Upadhayay, Ashish Dutt;Banerjee, Joyita;Chakrawarthy, Avinash;Chatterjee, Prashun;Lee, Jinkook;Dey, Aparajit Ballav
通讯作者：
Dey, Aparajit Ballav