The evolution of plasmid-carried antibiotic resistance.
The evolution of plasmid-carried antibiotic resistance.
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DOI：
10.1186/1471-2148-11-130
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发表时间：
2011-05-19
影响因子：
3.4
通讯作者：
Rankin DJ
中科院分区：
文献类型：
--
作者：
Svara F;Rankin DJ
抗生素耐药性是一个重大的公共卫生问题。当抗性基因移动时，通过质粒或噬菌体携带，它们的传播可以极大地加速。尤其是与抗生素耐药基因的传播有关的是质粒。然而，有利于携带抗药性基因的选择压力还没有完全确定。在这里，我们用不同抗生素治疗方案下的质粒动力学数学模型来解决这个问题。我们发现，质粒的传播是影响质粒携带的抗生素耐药性的关键因素，但治疗的剂量和间隔也很重要。当携带抗性基因的质粒与其他不携带抗性基因的质粒竞争时，我们的结果也是成立的。通过改变抗生素治疗之间的间隔和抗生素的剂量，我们表明不同的治疗方案可以选择携带质粒或染色体携带的耐药性。我们的研究解决了环境变化对携带质粒的抗生素耐药性进化的影响。
Antibiotic resistance represents a significant public health problem. When resistance genes are mobile, being carried on plasmids or phages, their spread can be greatly accelerated. Plasmids in particular have been implicated in the spread of antibiotic resistance genes. However, the selective pressures which favour plasmid-carried resistance genes have not been fully established. Here we address this issue with mathematical models of plasmid dynamics in response to different antibiotic treatment regimes. We show that transmission of plasmids is a key factor influencing plasmid-borne antibiotic resistance, but the dosage and interval between treatments is also important. Our results also hold when plasmids carrying the resistance gene are in competition with other plasmids that do not carry the resistance gene. By altering the interval between antibiotic treatments, and the dosage of antibiotic, we show that different treatment regimes can select for either plasmid-carried, or chromosome-carried, resistance. Our research addresses the effect of environmental variation on the evolution of plasmid-carried antibiotic resistance.
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