Single reach plans in dorsal premotor cortex during a two-target task.

Single reach plans in dorsal premotor cortex during a two-target task.
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DOI:
10.1038/s41467-018-05959-y
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发表时间:
2018-09-03
影响因子:
16.6
通讯作者:
Miller LE
Miller LE
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Dekleva BM;Kording KP;Miller LE

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在许多情况下,我们面临着多个潜在的行动,但必须等待更多的信息,然后才知道要执行哪一个。长期以来,运动科学家一直在问,在这些延迟反应的情况下,大脑是否同时计划两个潜在的运动,或者它只是选择一个,然后在必要时切换。为了回答这个问题,我们使用同时记录的猕猴背侧前运动皮层神经元群体的活动来跟踪两个潜在的到达目标之间的每时每刻的审议。我们发现,神经活动只表明一个单一的到达计划(一些目标比其他目标更受欢迎),并且最初的计划通常预测猴子在自由选择试验和不正确的暗示试验中的行为。我们的研究结果表明,运动前区皮层一次只计划一个选项,并且决策受到对可用运动选项的初始反应的强烈影响。运动皮层活动是否反映了多个潜在行动的计划,这是有争议的。在这里,作者报告说,在具有两个潜在到达目标的延迟反应任务中,背侧运动前皮质中的群体活动在任何时刻都只代表其中一个目标。
In many situations, we are faced with multiple potential actions, but must wait for more information before knowing which to perform. Movement scientists have long asked whether in these delayed-response situations the brain plans both potential movements simultaneously, or if it simply chooses one and then switches later if necessary. To answer this question, we used simultaneously recorded activity from populations of neurons in macaque dorsal premotor cortex to track moment-by-moment deliberation between two potential reach targets. We found that the neural activity only ever indicated a single-reach plan (with some targets favored more than others), and that initial plans often predicted the monkeys’ behavior on both Free-Choice trials and incorrect Cued trials. Our results suggest that premotor cortex plans only one option at a time, and that decisions are strongly influenced by the initial response to the available set of movement options. It is debated whether motor cortical activity reflects plans for multiple potential actions. Here, the authors report that in a delayed response task with two potential reach targets, population activity in the dorsal premotor cortex at any moment in time represents only one of the targets.
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