The additive impact of cardio-metabolic disorders and psychiatric illnesses on accelerated brain aging.
The additive impact of cardio-metabolic disorders and psychiatric illnesses on accelerated brain aging.
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DOI：
10.1002/hbm.25769
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发表时间：
2022-04-15
影响因子：
4.8
通讯作者：
Kochunov P
中科院分区：
文献类型：
--
作者：
Ryan MC;Hong LE;Hatch KS;Gao S;Chen S;Haerian K;Wang J;Goldwaser EL;Du X;Adhikari BM;Bruce H;Hare S;Kvarta MD;Jahanshad N;Nichols TE;Thompson PM;Kochunov P
严重精神疾病（SMI），包括重度抑郁症（MDD），双相情感障碍（BD）和精神分裂症谱系障碍（SSD），会增加大脑加速老化的风险。心脏代谢紊乱（CMD）是SMI的常见合并症，对大脑健康产生负面影响。我们在一个独立的SSD队列（N = 206）中验证了线性分位数回归指数（QRI）方法对机器学习“BrainAge”指数的影响。我们在来自英国生物样本库的N = 1，618（604 M/1，014 F;平均年龄= 63.53 ± 7.38）例SMI受试者和N = 11，849（5，719 M/6，130 F; 64.42 ± 7.38）例对照者中测试了SMI和CMD对加速脑老化的直接和累加效应。受试者根据诊断状态进行细分：SMI+/CMD+（N = 665）、SMI+/CMD−（N = 964）、SMI−/CMD+（N = 3，765）、SMI−/CMD−（N = 8，083）。SMI（F = 40.47，p = 2.06 × 10−10）和CMD（F = 24.69，p = 6.82 × 10−7）显著独立影响SMI+的全脑QRI。SSD的作用最大（Cohen's d = 1.42），其次是BD（d = 0.55）和MDD（d = 0.15）。高血压对SMI+（d = 0.19）和SMI-（d = 0.14）有显著影响。SMI效应是直接的，独立于MD，校正抗精神病药物的影响后仍然显着。全脑QRI与白色高信号（WMH）的体积显著相关（p < 10−16）。然而，WMH与SMI没有显著相关性，并且由CMD驱动，主要是高血压（p < 10−16）。我们使用了一个简单而稳健的指标QRI，证明SMI和CMD对加速脑老化的累加效应。我们发现精神疾病对QRI的影响大于心脏代谢疾病。我们的研究结果表明，患有SMI的受试者应该是干预措施的目标之一，以防止与年龄相关的认知能力下降。严重的精神疾病，包括重度抑郁症、双相情感障碍和精神分裂症谱系障碍，会增加大脑加速老化的风险;心血管代谢障碍是常见的合并症，会对大脑健康产生负面影响。我们使用了一个简单而稳健的指标QRI，证明SMI和CMD对加速脑老化的累加效应。我们发现精神疾病对QRI的影响大于心脏代谢疾病。
Severe mental illnesses (SMI) including major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum disorder (SSD) elevate accelerated brain aging risks. Cardio‐metabolic disorders (CMD) are common comorbidities in SMI and negatively impact brain health. We validated a linear quantile regression index (QRI) approach against the machine learning “BrainAge” index in an independent SSD cohort (N = 206). We tested the direct and additive effects of SMI and CMD effects on accelerated brain aging in the N = 1,618 (604 M/1,014 F, average age = 63.53 ± 7.38) subjects with SMI and N = 11,849 (5,719 M/6,130 F; 64.42 ± 7.38) controls from the UK Biobank. Subjects were subdivided based on diagnostic status: SMI+/CMD+ (N = 665), SMI+/CMD− (N = 964), SMI−/CMD+ (N = 3,765), SMI−/CMD− (N = 8,083). SMI (F = 40.47, p = 2.06 × 10−10) and CMD (F = 24.69, p = 6.82 × 10−7) significantly, independently impacted whole‐brain QRI in SMI+. SSD had the largest effect (Cohen’s d = 1.42) then BD (d = 0.55), and MDD (d = 0.15). Hypertension had a significant effect on SMI+ (d = 0.19) and SMI− (d = 0.14). SMI effects were direct, independent of MD, and remained significant after correcting for effects of antipsychotic medications. Whole‐brain QRI was significantly (p < 10−16) associated with the volume of white matter hyperintensities (WMH). However, WMH did not show significant association with SMI and was driven by CMD, chiefly hypertension (p < 10−16). We used a simple and robust index, QRI, the demonstrate additive effect of SMI and CMD on accelerated brain aging. We showed a greater effect of psychiatric illnesses on QRI compared to cardio‐metabolic illness. Our findings suggest that subjects with SMI should be among the targets for interventions to protect against age‐related cognitive decline. Severe mental illnesses including major depressive disorder, bipolar disorder, and schizophrenia spectrum disorder elevate accelerated brain aging risks; cardio‐metabolic disorders are common comorbidities and can negatively impact brain health. We used a simple and robust index, QRI, the demonstrate additive effect of SMI and CMD on accelerated brain aging. We showed a greater effect of psychiatric illnesses on QRI compared to cardio‐metabolic illness.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
影响因子：
5.7
作者：
Jahanshad, Neda;Kochunov, Peter V.;Sprooten, Emma;Mandl, Rene C.;Nichols, Thomas E.;Almasy, Laura;Blangero, John;Brouwer, Rachel M.;Curran, Joanne E.;de Zubicaray, Greig I.;Duggirala, Ravi;Fox, Peter T.;Hong, L. Elliot;Landman, Bennett A.;Martin, Nicholas G.;McMahon, Katie L.;Medland, Sarah E.;Mitchell, Braxton D.;Olvera, Rene L.;Peterson, Charles P.;Starr, John M.;Sussmann, Jessika E.;Toga, Arthur W.;Wardlaw, Joanna M.;Wright, Margaret J.;Pol, Hilleke E. Hulshoff;Bastin, Mark E.;McIntosh, Andrew M.;Deary, Ian J.;Thompson, Paul M.;Glahn, David C.
通讯作者：
Glahn, David C.
DOI：
10.1080/09540260902962198
发表时间：
2009
期刊：
International review of psychiatry (Abingdon, England)
影响因子：
--
作者：
Beyer JL;Young R;Kuchibhatla M;Krishnan KR
通讯作者：
Krishnan KR
影响因子：
4.8
作者：
Hennekens, CH;Hennekens, AR;Casey, DE
通讯作者：
Casey, DE