Relationship between spleen size and exercise tolerance in advanced heart failure patients with a left ventricular assist device.
Relationship between spleen size and exercise tolerance in advanced heart failure patients with a left ventricular assist device.
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DOI：
10.1186/s13104-022-05939-y
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发表时间：
2022-02-10
影响因子：
1.8
通讯作者：
Murohara T
中科院分区：
文献类型：
--
作者：
Hiraiwa H;Okumura T;Sawamura A;Araki T;Mizutani T;Kazama S;Kimura Y;Shibata N;Oishi H;Kuwayama T;Kondo T;Furusawa K;Morimoto R;Adachi T;Yamada S;Mutsuga M;Usui A;Murohara T
晚期心力衰竭(HF)患者植入左心辅助装置(LVAD)后脾体积增大。然而，这些患者的脾体积和运动耐量(最大耗氧量[VO2])之间的关系仍不清楚。在这项探索性研究中，我们招募了27名使用LVAD的心衰患者(中位年龄：46岁)。患者接受了血液检测、超声心动图、右心导管术、计算机断层扫描(CT)和心肺运动试验。用CT容积测量仪测量脾大小，并用结构方程模型确定影响VO2峰值的因素的相关性/因果关系。脾体积中位数为190.0毫升，最大摄氧量为13.2毫升/公斤/分。影响VO2峰值的因素有：峰值心率(HR；β = 0.402，P = .015)、肺毛细血管楔压(PCWP；β = − 0.698，P = .014)、右室每搏做功指数(β = 0.533，P = .001)、血中血红蛋白浓度(β = 0.359，P = .007)和脾体积(β = 0.215，P = .041)。脾体积与HR、PCWP和Hb峰值浓度相关，分别反映交感神经活性、心脏前负荷和携氧能力，因此与峰值VO2相关。这些结果表明，晚期心力衰竭患者的脾体积和运动耐量之间存在关联。网上版载有补充材料，可在10.1186/s13104022-05939-y查阅。
Spleen volume increases in patients with advanced heart failure (HF) after left ventricular assist device (LVAD) implantation. However, the relationship between spleen volume and exercise tolerance (peak oxygen consumption [VO2]) in these patients remains unknown. In this exploratory study, we enrolled 27 patients with HF using a LVAD (median age: 46 years). Patients underwent blood testing, echocardiography, right heart catheterization, computed tomography (CT), and cardiopulmonary exercise testing. Spleen size was measured using CT volumetry, and the correlations/causal relationships of factors affecting peak VO2 were identified using structural equation modeling. The median spleen volume was 190.0 mL, and peak VO2 was 13.2 mL/kg/min. The factors affecting peak VO2 were peak heart rate (HR; β = 0.402, P = .015), pulmonary capillary wedge pressure (PCWP; β = − 0.698, P = .014), right ventricular stroke work index (β = 0.533, P = .001), blood hemoglobin concentration (β = 0.359, P = .007), and spleen volume (β = 0.215, P = .041). Spleen volume correlated with peak HR, PCWP, and hemoglobin concentration, reflecting sympathetic activity, cardiac preload, and oxygen-carrying capacity, respectively, and was thus related to peak VO2. These results suggest an association between spleen volume and exercise tolerance in advanced HF. The online version contains supplementary material available at 10.1186/s13104-022-05939-y.
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DOI：
10.1016/j.healun.2013.03.004
发表时间：
2013-06
期刊：
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
影响因子：
--
作者：
Armstrong HF;Schulze PC;Kato TS;Bacchetta M;Thirapatarapong W;Bartels MN
通讯作者：
Bartels MN
影响因子：
8.9
作者：
Jung, Mette Holme;Gustafsson, Finn
通讯作者：
Gustafsson, Finn
影响因子：
12.8
作者：
Jahng JW;Song E;Sweeney G
通讯作者：
Sweeney G
影响因子：
3
作者：
Schagatay E;Lunde A;Nilsson S;Palm O;Lodin-Sundström A
通讯作者：
Lodin-Sundström A
影响因子：
4
作者：
Pernett F;Schagatay F;Vildevi C;Schagatay E
通讯作者：
Schagatay E