Spleen Contraction During Sudden Eupneic Hypoxia Elevates Hemoglobin Concentration.
Spleen Contraction During Sudden Eupneic Hypoxia Elevates Hemoglobin Concentration.
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DOI：
10.3389/fphys.2021.729123
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发表时间：
2021
影响因子：
4
通讯作者：
Schagatay E
中科院分区：
文献类型：
--
作者：
Pernett F;Schagatay F;Vildevi C;Schagatay E
在中等常压缺氧暴露20分钟时，脾脏逐渐收缩，使血红蛋白浓度（Hb）升高。然而，当氧气系统在高空跳伞、飞机机舱压降、气球飞行、极端海拔攀登和某些疾病中失效时，急性缺氧暴露可能会更短，更严重。我们的目的是评估脾脏在短时间暴露于极度缺氧时收缩的速度和幅度以及随后的氧气恢复。8名女性和7名男性志愿者在坐着休息时暴露在10%的常压缺氧环境中10分钟，然后再暴露在100%的氧气环境中10分钟。连续测量心率（HR）、动脉血氧饱和度（SpO2）、平均动脉血压（MAP）。每分钟超声显像测量脾脏体积计算，暴露前后取静脉血检测血红蛋白浓度（Hb）。暴露前平均脾体积（SD）为279 (115)mL，暴露3分钟时为219 (75)mL（减少21%，P = 0.005），缺氧暴露10分钟后为201 (93)mL（减少28%，P < 0.001）。暴露前Hb为138.8 (7.6)g·L−1，暴露10 min后Hb为142.9 (8.1)g·L−1（增加2.9%,P < 0.001）。暴露前SpO2为96.4(1.7)%，暴露最后一分钟为74.7(8.4)%（降低22.5%,P < 0.001）。暴露时心率从80 (14)bpm增加到90 (17)bpm（增加12%，P < 0.05）。MAP保持不变。氧恢复10 min后，脾脏体积和Hb值恢复，SpO2高于缺氧前，HR低于缺氧前。我们的结论是，急性常压缺氧仅10分钟，脾脏体积明显收缩，Hb升高。这种快速的脾脏反应，在暴露3分钟后就已经明显，可能在突然暴露于严重缺氧时具有保护作用。
The spleen contracts progressively during moderate normobaric hypoxia exposure of 20 min, which elevates hemoglobin concentration (Hb). However, acute hypoxia exposure could be shorter and more severe when oxygen systems fail during, e.g., high-altitude sky diving, aircraft cabin pressure drop, balloon flights, extreme altitude climbing, and in some maladies. We aimed to evaluate the speed and magnitude of spleen contraction during short exposure to extreme eupneic hypoxia and its subsequent recovery on oxygen. Eight female and seven male volunteers were exposed to normobaric hypoxia (10% oxygen) for 10 min during sitting rest, followed by 10 min on 100% oxygen. Heart rate (HR), arterial oxygen saturation (SpO2), and mean arterial blood pressure (MAP) were measured continuously. The spleen was measured via ultrasonic imaging every minute for volume calculations, and venous blood samples were drawn before and after exposure for hemoglobin concentration (Hb). Mean (SD) spleen volume was 279 (115) mL before exposure, 219 (75) mL (21% reduction; P = 0.005) at 3 min of exposure, and 201 (93) mL after 10 min exposure to hypoxia (28% reduction; P < 0.001). Hb was 138.8 (7.6) g·L−1 before and 142.9 (8.1) g·L−1 after 10 min of exposure (2.9% increase; P < 0.001). SpO2 was 96.4 (1.7)% before exposure and 74.7 (8.4)% during the last minute of exposure (22.5% reduction; P < 0.001). HR increased from 80 (14) to 90 (17) bpm during exposure (12% increase, P < 0.05). MAP remained unchanged. After 10 min recovery on oxygen, values had been restored for spleen volume and Hb, while SpO2 was higher and HR lower compared with before hypoxia exposure. We concluded that acute normobaric hypoxia of only 10 min caused significant spleen volume contraction with Hb increase. This rapid spleen response, evident already after 3 min of exposure, could have a protective effect during sudden exposure to severe hypoxia.
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