Maternal plasma pyridoxal-5'-phosphate concentrations and risk of isolated oral clefts in the Philippines.
Maternal plasma pyridoxal-5'-phosphate concentrations and risk of isolated oral clefts in the Philippines.
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菲律宾母亲血浆 5-磷酸吡哆醛浓度和孤立性口腔裂的风险。
DOI：
10.1002/bdra.20348
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Solon,Florentino
中科院分区：
文献类型：
--
作者：
Tamura,Tsunenobu;Munger,RonaldG;Nepomuceno,Buena;Corcoran,Christopher;Cembrano,Joselito;Solon,Florentino
BACKGROUNDWe report that inadequate vitamin B‐6 status of Filipino mothers, assessed by erythrocyte aspartate aminotransferase activity coefficient (EAST‐AC), is associated with an increased risk for isolated cleft lip with or without cleft palate (CL/P) in their children. Its association with the status assessed by plasma pyridoxal‐5′‐phosphate (PLP) concentrations is unknown.METHODSIn a case‐control study in the Philippines including 46 cases (mothers of a child with CL/P) and 392 controls (mothers of an unaffected child), we evaluated the association between the risk for CL/P and maternal vitamin B‐6 status assessed by PLP and EAST‐AC.RESULTSThe ORs of CL/P were estimated by classifying mothers by PLP (>30, 20–30, and <20 nmol/L). Using the highest PLP group as the reference, ORs (95% CIs) were 1.03 (0.45–2.37) and 2.66 (1.30–5.50) for the middle and lowest groups, respectively (ptrend = .01). In multivariate models controlling for various covariates including folate, the risk for CL/P was approximately 12 times higher in mothers with inadequate vitamin B‐6 status, assessed by both PLP and EAST‐AC values, compared to those with adequate status by both values.CONCLUSIONSInadequate vitamin B‐6 status assessed by maternal PLP and EAST‐AC values independently and both combined was associated with an increased risk for CL/P. The association was highest when both values were considered, suggesting that the measurement of both PLP and EAST‐AC provides better assessment of vitamin B‐6 status than either measurement alone. Birth Defects Research (Part A) 2007. © 2007 Wiley‐Liss, Inc.
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母亲的血浆锌浓度及其子女非综合征性口裂的风险：菲律宾的一项病例对照研究。
DOI：
10.1002/bdra.20179
发表时间：
2005
期刊：
Birth defects research. Part A, Clinical and molecular teratology
影响因子：
--
作者：
T. Tamura;R. Munger;C. Corcoran;Jocelyn Y Bacayao;B. Nepomuceno;F. Solon
通讯作者：
F. Solon
根据维生素 B-6 摄入量、营养状况和人体测量学，确定 7-12 岁儿童维生素 B-6 的估计平均需求量和推荐膳食摄入量。
DOI：
--
发表时间：
2002
期刊：
Journal of NutriLife
影响因子：
--
作者：
Sue;Yi;Li;Yi;Shou
通讯作者：
Shou
使用维生素 B-6 摄入量、营养状况和人体测量学评估 13-15 岁青少年维生素 B-6 的估计平均需求量和建议膳食摄入量。
DOI：
--
发表时间：
2003
期刊：
Journal of NutriLife
影响因子：
--
作者：
Sue;Li;Shou
通讯作者：
Shou
10-11 岁荷兰男孩的营养状况和食物消耗（荷兰营养监测系统）
影响因子：
3.6
作者：
G. Poppel;P. Schneijder;M. Löwik;J. Schrijver;Frans J. Kok
通讯作者：
Frans J. Kok
冷冻包装红细胞中维生素 B-6 依赖性转氨酶活性的稳定性取决于储存温度。
DOI：
--
发表时间：
2001
期刊：
Journal of NutriLife
影响因子：
--
作者：
J. Orlebeke;T. Stroet;D. Boomsma;C. Lanting;Václav Fidler;M. Huisman;Bert C.L. Touwen;E. Boersma
通讯作者：
E. Boersma