Modalities of aging in organisms with different strategies of resource allocation.
Modalities of aging in organisms with different strategies of resource allocation.
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DOI：
10.1016/j.arr.2022.101770
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发表时间：
2022-12
影响因子：
13.1
通讯作者：
中科院分区：
文献类型：
--
作者：
尽管衰老研究的进展在很大程度上依赖于理论框架，但今天在衰老生物学的许多关键问题上还没有达成共识。我假设，一个系统的分析，不同的进化机制的交叉点，老化与不同的资源分配策略，在不同的生物体可能调和老化假说。一次性索马，突变积累，拮抗多效性和生活史理论的应用被认为是在生物体与无性生殖，生物体与有性生殖和不确定的增长在不同条件下的外部死亡率，和生物体与确定的增长，恒温/恒温动物作为一个亚组。这篇综述表明，不同的衰老机制是相互补充的，在具有不同资源分配策略的生物体中，它们形成了从永生到自杀计划的衰老模式。它还改变了生长停滞在衰老中的作用。生长停滞在许多不同的生物群体中进化，这是从生长到繁殖的资源重新分配的结果（例如，单胎动物，全代谢昆虫），或从生长到营养储存（恒温动物/恒温动物）。不同动物谱系中的生长停滞具有相似的分子机制和相似的长寿后果，这是由于生长促进和生长抑制程序之间的冲突以及再生能力的抑制。
Although the progress of aging research relies heavily on a theoretical framework, today there is no consensus on many critical questions in aging biology. I hypothesize that a systematic analysis of the intersection of different evolutionary mechanisms of aging with diverse resource allocation strategies in different organisms may reconcile aging hypotheses. The application of disposable soma, mutation accumulation, antagonistic pleiotropy, and life-history theory is considered across organisms with asexual reproduction, organisms with sexual reproduction and indeterminate growth in different conditions of extrinsic mortality, and organisms with determinate growth, with endotherms/homeotherms as a subgroup. This review demonstrates that different aging mechanisms are complementary to each other, and in organisms with different resource allocation strategies they form aging modalities ranging from immortality to suicidal programs. It also revamps the role of growth arrest in aging. Growth arrest evolved in many different groups of organisms as a result of resource reallocation from growth to reproduction (e.g., semelparous animals, holometabolic insects), or from growth to nutrient storage (endotherms/homeotherms). Growth arrest in different animal lineages has similar molecular mechanisms and similar consequences for longevity due to the conflict between growth-promoting and growth-suppressing programs and suppression of regenerative capacity.
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影响因子：
2.8
作者：
Carter, DR;Mikic, B;Padian, K
通讯作者：
Padian, K
DOI：
10.1016/0162-3095(88)90027-1
发表时间：
1988-11-01
期刊：
ETHOLOGY AND SOCIOBIOLOGY
影响因子：
--
作者：
ALBIN, RL
通讯作者：
ALBIN, RL
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
7.8
作者：
Barardo D;Thornton D;Thoppil H;Walsh M;Sharifi S;Ferreira S;Anžič A;Fernandes M;Monteiro P;Grum T;Cordeiro R;De-Souza EA;Budovsky A;Araujo N;Gruber J;Petrascheck M;Fraifeld VE;Zhavoronkov A;Moskalev A;de Magalhães JP
通讯作者：
de Magalhães JP
影响因子：
5.2
作者：
Allard JB;Duan C
通讯作者：
Duan C