IPA1 functions as a downstream transcription factor repressed by D53 in strigolactone signaling in rice.
IPA1 functions as a downstream transcription factor repressed by D53 in strigolactone signaling in rice.
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IPA1 在水稻中作为独脚金内酯信号传导中受 D53 抑制的下游转录因子发挥作用。
DOI：
10.1038/cr.2017.102
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发表时间：
2017-09
期刊：
影响因子：
44.1
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Song X;Lu Z;Yu H;Shao G;Xiong J;Meng X;Jing Y;Liu G;Xiong G;Duan J;Yao XF;Liu CM;Li H;Wang Y;Li J
独脚金内酯（SL）是一类类胡萝卜素衍生的萜类内酯，是一种从根到茎的植物激素，通过抑制腋芽的生长来抑制茎的分支。DWARF 53（D53）是SL信号通路的关键阻遏物，推测其调节SL应答的下游转录网络。然而，还没有D53靶向的下游转录因子的报道。在这里，我们报告理想的植物结构1（IPA1），在水稻的植物结构的关键调节器，作为D53的直接下游组件在调节分蘖数和SL诱导的基因表达的功能。我们发现D53在体内和体外与IPA1相互作用，并抑制IPA1的转录激活活性。我们进一步发现IPA1可以直接结合到D53启动子，并在SL诱导的D53表达的反馈调节中起关键作用。这些结果表明，IPA1可能是长期推测的转录因子之一，与D53一起介导SL调控的水稻分蘖发育。
Strigolactones (SLs), a group of carotenoid derived terpenoid lactones, are root-to-shoot phytohormones suppressing shoot branching by inhibiting the outgrowth of axillary buds. DWARF 53 (D53), the key repressor of the SL signaling pathway, is speculated to regulate the downstream transcriptional network of the SL response. However, no downstream transcription factor targeted by D53 has yet been reported. Here we report that Ideal Plant Architecture 1 (IPA1), a key regulator of the plant architecture in rice, functions as a direct downstream component of D53 in regulating tiller number and SL-induced gene expression. We showed that D53 interacts with IPA1 in vivo and in vitro and suppresses the transcriptional activation activity of IPA1. We further showed that IPA1 could directly bind to the D53 promoter and plays a critical role in the feedback regulation of SL-induced D53 expression. These findings reveal that IPA1 is likely one of the long-speculated transcription factors that act with D53 to mediate the SL-regulated tiller development in rice.
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影响因子：
2.4
作者：
Bennett T;Liang Y;Seale M;Ward S;Müller D;Leyser O
通讯作者：
Leyser O
影响因子：
5.1
作者：
Bart R;Chern M;Park CJ;Bartley L;Ronald PC
通讯作者：
Ronald PC
影响因子：
5.1
作者：
Gao, Zhenyu;Qian, Qian;Han, Bin
通讯作者：
Han, Bin
影响因子：
9.2
作者：
Booker, J;Auldridge, M;Leyser, O
通讯作者：
Leyser, O
影响因子：
9.2
作者：
Hamiaux, Cyril;Drummond, Revel S. M.;Snowden, Kimberley C.
通讯作者：
Snowden, Kimberley C.