Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung.
Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung.
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DOI：
10.1021/nl202515a
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发表时间：
2011-12-14
期刊：
影响因子：
10.8
通讯作者：
Mutlu GM
中科院分区：
文献类型：
--
作者：
Duch MC;Budinger GR;Liang YT;Soberanes S;Urich D;Chiarella SE;Campochiaro LA;Gonzalez A;Chandel NS;Hersam MC;Mutlu GM
为了促进石墨烯及其衍生物氧化石墨烯（GO）在广泛应用中的拟议用途，我们探索了提高石墨烯纳米材料在肺部生物相容性的策略。特别是，将聚集态石墨烯、普朗尼克分散的石墨烯和氧化石墨烯溶液直接注入小鼠肺部。氧化石墨烯的引入导致了严重且持续的肺部损伤。此外，在细胞中，氧化石墨烯提高了线粒体呼吸速率和活性氧物质的产生，激活了炎症和凋亡途径。相比之下，液相剥离后的原始石墨烯的这种毒性显著降低，并且当未氧化的石墨烯用嵌段共聚物普朗尼克良好分散时，毒性进一步降至最低。我们的结果表明，石墨烯的共价氧化是其肺部毒性的主要原因，并表明原始石墨烯在普朗尼克中的分散为二维碳纳米材料的安全处理和潜在生物医学应用提供了一条途径。
To facilitate the proposed use of graphene and its derivative graphene oxide (GO) in widespread applications, we explored strategies that improve the biocompatibility of graphene nanomaterials in the lung. In particular, solutions of aggregated graphene, Pluronic dispersed graphene, and GO were administered directly into the lungs of mice. The introduction of GO resulted in severe and persistent lung injury. Furthermore, in cells, GO increased the rate of mitochondrial respiration and the generation of reactive oxygen species, activating inflammatory and apoptotic pathways. In contrast, this toxicity was significantly reduced in the case of pristine graphene after liquid phase exfoliation, and was further minimized when the unoxidized graphene was well-dispersed with the block copolymer Pluronic. Our results demonstrate that the covalent oxidation of graphene is a major contributor to its pulmonary toxicity and suggest that dispersion of pristine graphene in Pluronic provides a pathway for the safe handling and potential biomedical application of two-dimensional carbon nanomaterials.
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影响因子：
9.9
作者：
Sun, Xiaoming;Liu, Zhuang;Dai, Hongjie
通讯作者：
Dai, Hongjie
影响因子：
10.8
作者：
Mutlu GM;Budinger GR;Green AA;Urich D;Soberanes S;Chiarella SE;Alheid GF;McCrimmon DR;Szleifer I;Hersam MC
通讯作者：
Hersam MC
多壁碳纳米管对大鼠的毒理学作用
影响因子：
2.5
作者：
Liu, Aihong;Sun, Kangning;Zhao, Dongmei
通讯作者：
Zhao, Dongmei
DOI：
10.1073/pnas.0509009103
发表时间：
2006-02-28
影响因子：
11.1
作者：
Singh, R;Pantarotto, D;Kostarelos, K
通讯作者：
Kostarelos, K
影响因子：
4.8
作者：
Hanson, GT;Aggeler, R;Remington, SJ
通讯作者：
Remington, SJ