Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity.
Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity.
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DOI：
10.1021/nl9042483
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发表时间：
2010-05-12
期刊：
影响因子：
10.8
通讯作者：
Hersam MC
中科院分区：
文献类型：
--
作者：
Mutlu GM;Budinger GR;Green AA;Urich D;Soberanes S;Chiarella SE;Alheid GF;McCrimmon DR;Szleifer I;Hersam MC
单壁碳纳米管（SWCNTs）具有诱人的物理和化学特性，但人们对其潜在健康风险的担忧使其热度有所降温。在此我们研究纳米级分散的单壁碳纳米管（平均直径约1纳米）的肺毒性。由于单壁碳纳米管的分散使其相对于生产出的聚集体纵横比增大，我们直接检验了一个主流假设，即与其他碳结构相比，单壁碳纳米管相关的肺毒性是由于单个颗粒的大纵横比所致。将其气管内给药小鼠30天后，在接受聚集态单壁碳纳米管处理的小鼠的大气道中观察到的伴有轻度纤维化的肉芽肿样结构，在接受纳米级分散单壁碳纳米管处理的小鼠中未出现。对接受纳米级分散单壁碳纳米管处理的小鼠的肺切片进行检查发现，巨噬细胞摄取了单壁碳纳米管，并且随着时间推移逐渐清除。我们得出结论，单壁碳纳米管在体内的毒性是由于纳米材料的聚集，而非单个纳米管的大纵横比。生物相容性纳米级分散为制备毒性极小的纯化单壁碳纳米管制剂提供了一种可扩展的方法，从而使其能够在商业和生物医学应用中安全使用。
Excitement surrounding the attractive physical and chemical characteristics of single walled carbon nanotubes (SWCNTs) has been tempered by concerns regarding their potential health risks. Here we consider the lung toxicity of nanoscale dispersed SWCNTs (mean diameter ~ 1 nm). Because dispersion of the SWCNTs increases their aspect ratio relative to as-produced aggregates, we directly test the prevailing hypothesis that lung toxicity associated with SWCNTs compared with other carbon structures is attributable to the large aspect ratio of the individual particles. Thirty days after their intratracheal administration to mice, the granuloma-like structures with mild fibrosis in the large airways observed in mice treated with aggregated SWCNTs were absent in mice treated with nanoscale dispersed SWCNTs. Examination of lung sections from mice treated with nanoscale dispersed SWCNTs revealed uptake of the SWCNTs by macrophages and gradual clearance over time. We conclude that the toxicity of SWCNTs in vivo is attributable to aggregation of the nanomaterial rather than the large aspect ratio of the individual nanotubes. Biocompatible nanoscale dispersion provides a scalable method to generate purified preparations of SWCNTs with minimal toxicity, thus allowing them to be used safely in commercial and biomedical applications.
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DOI：
10.1056/nejmsa0805646
发表时间：
2009-01-22
期刊：
The New England journal of medicine
影响因子：
--
作者：
Pope CA 3rd;Ezzati M;Dockery DW
通讯作者：
Dockery DW
影响因子：
56.9
作者：
O'Connell, MJ;Bachilo, SM;Smalley, RE
通讯作者：
Smalley, RE
影响因子：
38.3
作者：
Green, Alexander A.;Hersam, Mark C.
通讯作者：
Hersam, Mark C.
影响因子：
9.9
作者：
Liu, Zhuang;Tabakman, Scott;Welsher, Kevin;Dai, Hongjie
通讯作者：
Dai, Hongjie
影响因子：
38.3
作者：
Poland, Craig A.;Duffin, Rodger;Donaldson, Ken
通讯作者：
Donaldson, Ken