Procedural pain and oxidative stress in premature neonates.
Procedural pain and oxidative stress in premature neonates.
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DOI：
10.1016/j.jpain.2012.03.010
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发表时间：
2012-06
期刊：
影响因子：
4
通讯作者：
Angeles, Danilyn M.
中科院分区：
文献类型：
--
作者：
Slater, Laurel;Asmerom, Yayesh;Boskovic, Danilo S.;Bahjri, Khaled;Plank, Megan S.;Angeles, Katherine R.;Phillips, Raylene;Deming, Douglas;Ashwal, Stephen;Hougland, Kristen;Fayard, Elba;Angeles, Danilyn M.
暴露于疼痛的NICU程序的早产儿表现出疼痛评分增加以及氧合和心率改变。目前尚不清楚这些生理反应是否会增加氧化应激的风险。采用前瞻性研究设计，我们研究了80名早产儿的组织损伤程序（TDP，在留置中心动脉或静脉导管中断期间拆除胶带）与氧化应激之间的关系。通过测量新生儿经历TDP前后（n=38）与未经历任何TDP的新生儿（对照组，n=42）的血浆中尿酸（UA）和丙二醛（MDA）浓度来量化氧化应激。在TDP之前和期间使用早产儿疼痛特征（PIPP）测量疼痛。我们发现TDP组的疼痛评分高于对照组（中位数评分分别为11和5，P<0.001）。对照组新生儿的UA随时间显著降低，但TDP组新生儿的UA保持稳定（132.76μM至123.23μM vs.140.50μM至138.9μM，P=0.002）。对照组新生儿的MDA水平随时间降低，但TDP组新生儿的MDA水平升高（2.07μM至1.81μM vs. 2.07μM至2.21μM，P=0.01）。我们发现PIPP评分和MDA之间存在显著的正相关。我们的数据表明早产儿手术疼痛和氧化应激之间存在显著关系。
Preterm neonates exposed to painful NICU procedures exhibit increased pain scores and alterations in oxygenation and heart rate. It is unclear whether these physiologic responses increase the risk of oxidative stress. Using a prospective study design, we examined the relationship between a tissue-damaging procedure (TDP, tape removal during discontinuation of an indwelling central arterial or venous catheter) and oxidative stress in 80 preterm neonates. Oxidative stress was quantified by measuring uric acid (UA) and malondialdehyde (MDA) concentration in plasma before and after neonates experienced a TDP (n=38) compared to those not experiencing any TDP (control group, n=42). Pain was measured before and during the TDP using the Premature Infant Pain Profile(PIPP). We found that pain scores were higher in the TDP group compared to the control group (median scores:11 and 5, respectively, P<0.001). UA significantly decreased over time in control neonates but remained stable in TDP neonates (132.76μM to 123.23μM vs.140.50μM to 138.9μM, P=0.002). MDA levels decreased over time in control neonates but increased in TDP neonates (2.07μM to 1.81μM vs. 2.07μM to 2.21μM, P=0.01). We found significant positive correlations between PIPP scores and MDA. Our data suggest a significant relationship between procedural pain and oxidative stress in preterm neonates.
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影响因子：
3.3
作者：
HORTON, JW;WALKER, PB
通讯作者：
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影响因子：
168.9
作者：
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作者：
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通讯作者：
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DOI：
10.1159/000074954
发表时间：
2004-01-01
期刊：
BIOLOGY OF THE NEONATE
影响因子：
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作者：
Boyer, K;Johnston, C;Sherrard, A
通讯作者：
Sherrard, A
DOI：
10.1111/j.1447-0756.2008.00802.x
发表时间：
2008-12-01
影响因子：
1.6
作者：
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通讯作者：
Yurekli, Muhuttin