Traveling waves in actin dynamics and cell motility.

Traveling waves in actin dynamics and cell motility.
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DOI:
10.1016/j.ceb.2012.08.012
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发表时间:
2013-02
影响因子:
7.5
通讯作者:
Mogilner, Alex
Mogilner, Alex
中科院分区:
生物学2区
文献类型:
--
作者:
Allard, Jun;Mogilner, Alex

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Much of current understanding of cell motility arose from studying steady treadmilling of actin arrays. Recently, there have been a growing number of observations of a more complex, non-steady, actin behavior, including self-organized waves. It is becoming clear that these waves result from activation and inhibition feedbacks in actin dynamics acting on different scales, but the exact molecular nature of these feedbacks and respective roles of biomechanics and biochemistry are still unclear. Here, we review recent advances achieved in experimental and theoretical studies of actin waves and discuss mechanisms and physiological significance of wavy protrusions.
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