Intravitreal triamcinolone acetonide for the treatment of immune recovery uveitis macular edema.
Intravitreal triamcinolone acetonide for the treatment of immune recovery uveitis macular edema.
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玻璃体内注射曲安奈德用于治疗免疫恢复性葡萄膜炎黄斑水肿。
DOI：
10.1016/j.ophtha.2006.07.013
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发表时间：
2007
期刊：
影响因子：
13.7
通讯作者：
Freeman,WilliamR
中科院分区：
文献类型：
--
作者：
Morrison,VictoriaL;Kozak,Igor;LaBree,LaurieD;Azen,StanleyP;Kayicioglu,OzcanO;Freeman,WilliamR
PURPOSETo evaluate the use of intravitreal triamcinolone (IVTA) for the treatment of macular edema secondary to immune recovery uveitis (IRU) in patients with AIDS.DESIGNProspective, consecutive, interventional case series.PARTICIPANTSEight eyes of 7 patients receiving 13 injections.METHODSProspective, consecutive, interventional case series of 13 injections involving 8 eyes in 7 patients who underwent an intravitreal injection of 20 mg decanted triamcinolone acetate for fluorescein angiographically proven IRU-related macular edema.MAIN OUTCOME MEASURESThe primary outcome measure was vision (using the Early Treatment Diabetic Retinopathy Study chart). Other outcome measures included fluorescein angiography and optical coherence tomography.RESULTSVisual acuity improved at all time points and was statistically significant at the 1-month and 3-month follow-up examinations. The average visual improvement was 3 lines at 3 months. Retinal volume and thickness improvement were statistically significant at all time points. All patients had a minimum follow-up of 9 months, and there were no cases of cytomegalovirus reactivation.CONCLUSIONSPrevious studies showed that treatment with sub-Tenon repository steroids for the treatment of macular edema of IRU was only marginally effective. However, the current study shows that IVTA can be an effective short-term treatment for macular edema secondary to IRU in patients with AIDS. Longer follow-up is needed to assess the durability of the effect and to monitor for longer-term complications and outcomes.
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影响因子：
6.4
作者：
Karavellas, MP;Plummer, DJ;Freeman, WR
通讯作者：
Freeman, WR
采用高活性抗逆转录病毒疗法治疗后痊愈的患者巨细胞病毒性视网膜炎再激活的特征
DOI：
10.1097/00006982-200002000-00007
发表时间：
2000
期刊：
Retina
影响因子：
--
作者：
Mi;M. P. Karavellas;D. Plummer;W. Freeman
通讯作者：
W. Freeman
DOI：
10.1056/nejm199512073332204
发表时间：
1995-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
M. Markowitz;M. Saag;W. Powderly;A. Hurley;A. Hsu;J. Valdes;D. Henry;F. Sattler;Anthony F. La Marca;J. Leonard;D. Ho
通讯作者：
M. Markowitz;M. Saag;W. Powderly;A. Hurley;A. Hsu;J. Valdes;D. Henry;F. Sattler;Anthony F. La Marca;J. Leonard;D. Ho
DOI：
10.1097/00006982-200406000-00007
发表时间：
2004-06-01
影响因子：
3.3
作者：
El-Bradey, MH;Cheng, LY;Freeman, WR
通讯作者：
Freeman, WR
影响因子：
4.1
作者：
C. L. Shields;Hakan Demirci;J. A. Shields;Christopher Spanich
通讯作者：
C. L. Shields;Hakan Demirci;J. A. Shields;Christopher Spanich