Design of a multiple drug delivery system directed at periodontitis.
Design of a multiple drug delivery system directed at periodontitis.
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DOI：
10.1016/j.biomaterials.2013.07.093
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发表时间：
2013-11
期刊：
影响因子：
14
通讯作者：
Puleo, David A.
中科院分区：
文献类型：
--
作者：
Sundararaj, Sharath C.;Thomas, Mark V.;Peyyala, Rebecca;Dziubla, Thomas D.;Puleo, David A.
牙周病非常普遍，世界人口中有90%受到牙周炎或其前期病症牙龈炎的影响。这些病症是由牙齿上的细菌生物膜引起的，细菌生物膜刺激慢性炎症反应，导致牙槽骨损失，最终导致牙齿损失。目前牙周炎的治疗方法针对疾病的特定部分，没有单独的治疗作为完整的治疗。本研究旨在展示一种多药递药系统的发展，逐步治疗不同阶段的牙周病。更具体地，多层膜由包含邻苯二甲酸乙酸纤维素和Pluronic F-127的缔合聚合物制成，以实现药物的顺序释放。使用的四种药物分别是甲硝唑、酮洛芬、多西环素和辛伐他汀，以消除感染、抑制炎症、防止组织破坏和帮助骨再生。不同的侵蚀时间和可调的顺序释放曲线，实现了通过修改层的数量或通过列入一个缓慢侵蚀的聚合物层。抗生素和抗炎活性分析表明，从装置释放的药物保留100%的生物活性。多层CAPP递送系统提供了一种基于牙周炎的发病机理和其他条件释放不同药物的通用方法。
Periodontal disease is highly prevalent, with 90% of the world population affected by either periodontitis or its preceding condition, gingivitis. These conditions are caused by bacterial biofilms on teeth, which stimulate a chronic inflammatory response that leads to loss of alveolar bone and, ultimately, the tooth. Current treatment methods for periodontitis address specific parts of the disease, with no individual treatment serving as a complete therapy. The present research sought to demonstrate development of a multiple drug delivery system for stepwise treatment of different stages of periodontal disease. More specifically, multilayered films were fabricated from an association polymer comprising cellulose acetate phthalate and Pluronic F-127 to achieve sequential release of drugs. The four types of drugs used were metronidazole, ketoprofen, doxycycline, and simvastatin to eliminate infection, inhibit inflammation, prevent tissue destruction, and aid bone regeneration, respectively. Different erosion times and adjustable sequential release profiles were achieved by modifying the number of layers or by inclusion of a slower-eroding polymer layer. Analysis of antibiotic and anti-inflammatory bioactivity showed that drugs released from the devices retained 100% bioactivity. The multilayered CAPP delivery system offers a versatile approach for releasing different drugs based on the pathogenesis of periodontitis and other conditions.
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