Suppression of host adaptive immune responses by Neisseria gonorrhoeae: role of interleukin 10 and type 1 regulatory T cells.
Suppression of host adaptive immune responses by Neisseria gonorrhoeae: role of interleukin 10 and type 1 regulatory T cells.
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淋病奈瑟菌感染引发强烈的炎症反应，其特征是中性粒细胞流入生殖道，但自然淋球菌感染不会诱导保护性免疫状态。我们以前的研究在小鼠模型N。淋病感染表明，TGF-β参与了这种生物体对获得性免疫的抑制，但TGF-β活性的完全抑制仅部分逆转了N.淋病介导的Th 1和Th 2应答的抑制。在这项研究中，我们表明，N。淋病强烈诱导IL-10和1型调节性T（Tr 1）细胞的产生。IL-10和Tr 1细胞活性的阻断增强了Th 1/Th 2依赖的适应性免疫应答和Th 17控制的先天性应答。淋病在淋球菌攻击期间用抗IL-10抗体治疗小鼠导致感染的更快清除，并诱导对继发感染的保护，产生循环和阴道抗淋球菌抗体。我们的研究结果表明，抑制IL-10和Tr 1细胞提供了一种新的方法来治疗淋病，并促进特异性保护性免疫的发展。
Infection with Neisseria gonorrhoeae triggers an intense inflammatory response characterized by an influx of neutrophils in the genital tract, yet natural gonococcal infection does not induce a state of protective immunity. Our previous studies in a mouse model of N. gonorrhoeae infection demonstrated that TGF-β is involved in the suppression of adaptive immunity by this organism, but complete inhibition of TGF-β activity only partially reverses N. gonorrhoeae-mediated suppression of Th1 and Th2 responses. In this study, we show that N. gonorrhoeae strongly induced the production of IL-10 and type 1 regulatory T (Tr1) cells. Blockade of IL-10 and Tr1 cell activity enhanced both Th1/Th2-dependent adaptive immune responses and Th17-governed innate responses to N. gonorrhoeae. Treatment of mice with anti-IL-10 antibody during gonococcal challenge led to faster clearance of infection and induced protection against secondary infection, with the generation of circulating and vaginal anti-gonococcal antibodies. Our results suggest that inhibition of IL-10 and Tr1 cells affords a new approach to the treatment of gonorrhea and facilitates the development of specific protective immunity.
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影响因子：
8
作者：
通讯作者：
--
影响因子：
15.9
作者：
PLUMMER, FA;SIMONSEN, JN;NGUGI, EN
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NGUGI, EN
影响因子：
32.4
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Huber S;Gagliani N;Esplugues E;O'Connor W Jr;Huber FJ;Chaudhry A;Kamanaka M;Kobayashi Y;Booth CJ;Rudensky AY;Roncarolo MG;Battaglia M;Flavell RA
通讯作者：
Flavell RA
影响因子：
6.5
作者：
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通讯作者：
Jarvis, Gary A.
影响因子：
4.8
作者：
Kreisman, Lori S. C.;Cobb, Brian A.
通讯作者：
Cobb, Brian A.