Heterogeneity of bronchoconstriction does not distinguish mild asthmatic subjects from healthy controls when supine.
Heterogeneity of bronchoconstriction does not distinguish mild asthmatic subjects from healthy controls when supine.
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仰卧时支气管收缩的异质性并不能区分轻度哮喘受试者和健康对照。
DOI：
10.1152/japplphysiol.00519.2007
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Bates,JasonHT
中科院分区：
文献类型：
--
作者：
Kaminsky,DavidA;Irvin,CharlesG;Lundblad,LennartKA;Thompson-Figueroa,John;Klein,Jeffrey;Sullivan,MichaelJ;Flynn,Frank;Lang,Sherburn;Bourassa,Lorraine;Burns,Stephanie;Bates,JasonHT
异质性是气道收缩的基本特性。然而，这是否是轻度哮喘的一个显着特征尚不清楚。我们使用计算机断层扫描和强制振荡技术来比较 18 名轻度哮喘受试者和 19 名健康对照受试者在仰卧时支气管收缩程度相似的情况下的肺部异质性。我们还评估了深吸入和沙丁胺醇对仰卧位肺力学的影响。异质性的测量包括肺衰减（我们从中得出了空气空间大小的新指数）以及呼吸系统阻力在 1 至 20 Hz 之间的频率依赖性。我们发现，与对照组相比，哮喘受试者在坐位时对乙酰胆碱气道有高反应性，但两组仰卧吸入乙酰甲胆碱后 1 秒内用力呼气量的下降相似。在乙酰甲胆碱之前，两组之间的阻力频率依赖性或肺衰减没有基线差异，并且在乙酰甲胆碱之后，两组的反应相似，空气空间尺寸增加（+9.2% vs. +3.4%）、空气空间尺寸异质性（+9.8% vs. +4.2%）和阻力频率依赖性（+76% vs. +86%）。深吸不影响两组的抵抗力，但沙丁胺醇显着降低两组的抵抗力。我们的结论是，计算机断层扫描和强迫振荡技术都表明，仰卧时诱导支气管收缩期间气道狭窄的异质性增加，并且当支气管收缩到相同程度时，这种异质性在轻度哮喘受试者和健康对照之间是相当的。因此，异质性似乎是支气管收缩的基本特征，并且并非轻度哮喘所独有。
Heterogeneity is a fundamental property of airway constriction; however, whether it is a distinguishing feature of mild asthma is not clear. We used computerized tomography and the forced oscillation technique to compare lung heterogeneity between 18 mildly asthmatic and 19 healthy control subjects at similar levels of bronchoconstriction while subjects were supine. We also assessed the effects of deep inhalation and albuterol on supine lung mechanics. Measures of heterogeneity included lung attenuation, from which we derived a novel index of air-space size, and the frequency dependence of respiratory system resistance between 1 and 20 Hz. We found that asthmatic subjects had airways hyperresponsiveness to methacholine in the sitting position compared with controls, but both groups had similar falls in forced expiratory volume in 1 s after inhaling methacholine while supine. There were no baseline differences between the groups in the frequency dependence of resistance, or lung attenuation, before methacholine, and both groups responded similarly with an increase in air-space size (+9.2% vs. +3.4%), air-space size heterogeneity (+9.8% vs. +4.2%), and frequency dependence of resistance (+76% vs. +86%) after methacholine. Deep inhalation did not affect resistance in either group, but albuterol significantly reduced resistance in both groups. We conclude that both computerized tomography and the forced oscillation technique demonstrate increased heterogeneity of airway narrowing during induced bronchoconstriction while supine and that this heterogeneity is equivalent between subjects with mild asthma and healthy controls when bronchoconstricted to the same degree. Thus heterogeneity appears to be a fundamental feature of bronchoconstriction and is not unique to mild asthma.
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DOI：
10.1152/japplphysiol.00300.2004
发表时间：
2004
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Kaminsky,DavidA;Irvin,CharlesG;Lundblad,Lennart;Moriya,HenriqueT;Lang,Sherburn;Allen,Jennifer;Viola,Tracey;Lynn,Mary;Bates,JasonHT
通讯作者：
Bates,JasonHT
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影响因子：
3.2
作者：
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R. Darling
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DOI：
--
发表时间：
1987
期刊：
影响因子：
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作者：
A. Kusy
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A. Kusy
仰卧男性对乙酰甲胆碱的机械反应和深度吸气。
影响因子：
3.3
作者：
Maurizio Meinero;G. Coletta;L. Dutto;M. Milanese;Giorgio Nova;A. Sciolla;R. Pellegrino;V. Brusasco
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V. Brusasco
姿势对哮喘呼气流量和气道对乙酰甲胆碱反应性的影响。
影响因子：
9.6
作者：
M. Tahan;L. Boulet
通讯作者：
L. Boulet