Mechanical response to methacholine and deep inspiration in supine men.
Mechanical response to methacholine and deep inspiration in supine men.
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仰卧男性对乙酰甲胆碱的机械反应和深度吸气。
DOI：
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发表时间：
2007
影响因子：
3.3
通讯作者：
V. Brusasco
中科院分区：
文献类型：
--
作者：
Maurizio Meinero;G. Coletta;L. Dutto;M. Milanese;Giorgio Nova;A. Sciolla;R. Pellegrino;V. Brusasco
在7名男性志愿者中研究了仰卧位对吸入乙酰甲胆碱和深吸气（DI）的气道反应的影响。在对照日，受试者在乙酰甲胆碱吸入和肺功能测量期间均处于坐姿。第二次，在整个研究期间，受试者仰卧，重复整个程序。第三次，从坐位吸入乙酰甲胆碱，并在仰卧位进行测量。最后，在第四次时，从仰卧位吸入乙酰甲胆碱，并在坐位进行测量。从坐位到仰卧位，所有受试者的功能性残气量均下降约1升。当在仰卧位进行肺功能测量（肺阻力、动态弹性、残余容量和最大流量）时，对乙酰甲胆碱的反应大于对照组，这与DI后更严重的呼吸困难和更快的动态弹性恢复有关。相比之下，当乙酰甲胆碱在仰卧位吸入，但在坐位进行测量时，对乙酰甲胆碱的反应与对照日相似。这些发现证明了在夜间哮喘中，操作肺容量的减少在引起或维持气流阻塞方面的潜力。据推测，仰卧位时对乙酰甲胆碱的过度反应可能间接导致气道平滑肌适应短长度、气道壁水肿和大充气后气道更快再狭窄。
The effects of supine posture on airway responses to inhaled methacholine and deep inspiration (DI) were studied in seven male volunteers. On a control day, subjects were in a seated position during both methacholine inhalation and lung function measurements. On a second occasion, the whole procedure was repeated with the subjects lying supine for the entire duration of the study. On a third occasion, methacholine was inhaled from the seated position and measurements were taken in a supine position. Finally, on a fourth occasion, methacholine was inhaled from the supine position and measurements were taken in the seated position. Going from sitting to supine position, the functional residual capacity decreased by approximately 1 liter in all subjects. When lung function measurements (pulmonary resistance, dynamic elastance, residual volume, and maximal flows) were taken in supine position, the response to methacholine was greater than at control, and this was associated with a greater dyspnea and a faster recovery of dynamic elastance after DI. By contrast, when methacholine was inhaled in supine position but measurements were taken in sitting position, the response to methacholine was similar to control day. These findings document the potential of the decrease in the operational lung volumes in eliciting or sustaining airflow obstruction in nocturnal asthma. It is speculated that the exaggerated response to methacholine in the supine posture may variably contribute to airway smooth muscle adaptation to short length, airway wall edema, and faster airway renarrowing after a large inflation.
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DOI：
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DOI：
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期刊：
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影响因子：
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