Photoreactivating enzyme induction in human lymphocytes.

Photoreactivating enzyme induction in human lymphocytes.
复制标题

人淋巴细胞中的光活化酶诱导。

DOI:
10.1111/j.1751-1097.1982.tb03847.x
复制
发表时间:
1982
影响因子:
3.3
通讯作者:
Castellani,A
Castellani,A
中科院分区:
生物学3区
文献类型:
--
作者:
Sutherland,BM;Castellani,A

文献摘要

参考文献

被引文献

相似文献

测定在有丝分裂原植物血凝素(PHA)存在或不存在的情况下培养的人淋巴细胞的光复活酶(Pre)活性。在有PHA存在的情况下,光复活酶活性在约40h内从0上升到12pmol/mg/h,而在没有PHA的情况下,酶活性没有变化。Pre和乳酸脱氢酶(有丝分裂刺激的标志物)的诱导动力学没有区别,表明Pre的诱导是由有丝分裂原刺激转录和翻译的结果,而不是PHA对Pre产生的特定影响。在RPMI1640培养液中生长迅速的小鼠淋巴母细胞的Pre水平也高于在Dulbecco‘s培养液中生长较慢的小鼠淋巴母细胞。
Photoreactivating enzyme (PRE) activity was determined in human lymphocytes cultured in the presence or absence of the mitogen phytohemagglutinin (PHA). Photoreactivating enzyme activity increased from 0 to 12pmol/mg/h in about 40 h in cells cultured in the presence of PHA; enzyme activity was unchanged in the absence of PHA. The kinetics of induction of PRE and of lactate dehydrogenase, a marker of mitogenic stimulation, were indistinguishable, indicating that PRE induction results from stimulation of transcription and translation by the mitogen, rather than a specific effect of the PHA on PRE production. The level of PRE was also higher in mouse lymphoblasts growing rapidly in RPMI 1640 medium than in the same cells growing more slowly in Dulbecco's medium.
DOI: 10.1042/bj1250841
发表时间: 1971
期刊: The Biochemical journal
影响因子: --
作者:
P. F. Swann;P. Magee
通讯作者: P. Magee
DOI: 10.1073/pnas.71.3.639
发表时间: 1974-01-01
影响因子: 11.1
作者:
GOTH, R;RAJEWSKY, MF
通讯作者: RAJEWSKY, MF
大鼠肝脏 DNA 修复切除 O6-甲基鸟嘌呤的耗尽和恢复
DOI: 10.1038/259153a0
发表时间: 1976
期刊: Nature
影响因子: 64.8
作者:
P. Kleihues;G. Margison
通讯作者: G. Margison
二甲基亚硝胺引起的大鼠肾脏致癌损伤的可能修复
DOI: 10.1038/263134a0
发表时间: 1976
期刊: Nature
影响因子: 64.8
作者:
P. Swann;P. Magee;U. Mohr;G. Reznik;U. Green;D. Kaufman
通讯作者: D. Kaufman
从含有脱氧肌苷单磷酸残基的聚脱氧核苷酸和 DNA 中酶切游离次黄嘌呤。
DOI: --
发表时间: 1978
影响因子: 4.8
作者:
P. Karran;T. Lindahl
通讯作者: T. Lindahl