Altered Intranetwork and Internetwork Functional Connectivity in Type 2 Diabetes Mellitus With and Without Cognitive Impairment.
Altered Intranetwork and Internetwork Functional Connectivity in Type 2 Diabetes Mellitus With and Without Cognitive Impairment.
复制标题
有或没有认知障碍的 2 型糖尿病患者的网络内和互联网功能连接的改变
DOI：
10.1038/srep32980
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发表时间：
2016-09-13
影响因子：
4.6
通讯作者：
Zhu WZ
中科院分区：
文献类型：
--
作者：
Yang SQ;Xu ZP;Xiong Y;Zhan YF;Guo LY;Zhang S;Jiang RF;Yao YH;Qin YY;Wang JZ;Liu Y;Zhu WZ
2型糖尿病（T2DM）与认知功能障碍有关。我们通过静息态功能MRI研究了T2DM进展是否存在网络内部和网络间功能连接的改变。分析19例T2DM认知功能正常（DMCN）患者、19例T2DM认知功能损害（DMCI）患者和19例健康对照者的MRI资料。从完整性、网络和连通性3个层次研究了由5个静息态网络（RSN）系统[默认模式网络（DMN）、背侧注意网络（DAN）、控制网络（CON）、突显网络（SAL）和感觉运动网络（SMN）]组成的36个脑区之间的功能连通性。在三个层次的分析基础上，发现T2DM，尤其是DMCI的内部网络和网络间连接受损。主要累及双侧后小脑、右侧小脑、DMN和CON。研究发现，T2DM患者特定脑结构的功能连接强度与血红蛋白A1c（HbA1c）、认知评分和病程相关。这些与2型糖尿病所致脑功能损害相关的组间差异的网络改变表明，网络组织可能是预测2型糖尿病临床进展、评估认知损害和进一步了解2型糖尿病病理生理学的潜在生物标志物。
Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment. We investigated whether alterations of intranetwork and internetwork functional connectivity with T2DM progression exist, by using resting-state functional MRI. MRI data were analysed from 19 T2DM patients with normal cognition (DMCN) and 19 T2DM patients with cognitive impairment (DMCI), 19 healthy controls (HC). Functional connectivity among 36 previously well-defined brain regions which consisted of 5 resting-state network (RSN) systems [default mode network (DMN), dorsal attention network (DAN), control network (CON), salience network (SAL) and sensorimotor network (SMN)] was investigated at 3 levels (integrity, network and connectivity). Impaired intranetwork and internetwork connectivity were found in T2DM, especially in DMCI, on the basis of the three levels of analysis. The bilateral posterior cerebellum, the right insula, the DMN and the CON were mainly involved in these changes. The functional connectivity strength of specific brain architectures in T2DM was found to be associated with haemoglobin A1c (HbA1c), cognitive score and illness duration. These network alterations in intergroup differences, which were associated with brain functional impairment due to T2DM, indicate that network organizations might be potential biomarkers for predicting the clinical progression, evaluating the cognitive impairment, and further understanding the pathophysiology of T2DM.
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影响因子：
7.7
作者：
Musen G;Jacobson AM;Bolo NR;Simonson DC;Shenton ME;McCartney RL;Flores VL;Hoogenboom WS
通讯作者：
Hoogenboom WS
阿尔茨海默病中的长距离功能连接和加权网络架构受损。
影响因子：
3.7
作者：
Liu, Yong;Yu, Chunshui;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
DOI：
10.1146/annurev-clinpsy-040510-143934
发表时间：
2011-01-01
影响因子：
18.4
作者：
Bullmore, Edward T.;Bassett, Danielle S.
通讯作者：
Bassett, Danielle S.
影响因子：
4.8
作者：
Jiang, TZ;He, Y;Weng, XC
通讯作者：
Weng, XC