Comparison of chrysene metabolism in epithelial human bronchial and Syrian hamster lung cells.
Comparison of chrysene metabolism in epithelial human bronchial and Syrian hamster lung cells.
复制标题
人支气管上皮细胞和叙利亚仓鼠肺细胞中的代谢比较。
DOI：
10.1016/0304-3835(87)90212-6
复制
发表时间：
1987
期刊：
影响因子：
9.7
通讯作者：
U. Mohr
中科院分区：
文献类型：
--
作者：
J. Jacob;G. Grimmer;G. Raab;M. Emura;M. Riebe;U. Mohr
Abstract Chrysene is metabolized to 1-, 2-, 3-, and 4-hydroxychrysene and trans-1, 2-as well as trans-3, 4-dihydroxydihydrochrysene in human and Syrian hamster epithelial lung cells as indicated by GC MS analysis, whereas K-region oxidation is at most a very minor pathway. Cells of a permanent clonal line of fetal hamster lung metabolized 97% of the chrysene whereas fetal human bronchial epithelial cells converted 24% of the substrate within 8 days incubation. In human cells oxidation at the 3, 4-position predominates, whereas oxidation at the 1, 2-position is the major pathway in hamster cells. Indication for a bay-region oxidation of chrysene in hamster cells has been obtained.
9-羟基-1,2-二醇的形成作为屈代谢活化的中间体。
影响因子：
4.7
作者：
Hodgson,RM;Seidel,A;Bochnitschek,W;Glatt,HR;Oesch,F;Grover,PL
通讯作者：
Grover,PL
小鼠皮肤中的代谢激活：三醇环氧化物参与的证据。
影响因子：
4.7
作者：
Hodgson,RM;Weston,A;Grover,PL
通讯作者：
Grover,PL
影响因子：
4.7
作者：
Hodgson,RM;Pal,K;Grover,PL;Sims,P
通讯作者：
Sims,P