Initial emergency department diagnosis and management of adult patients with severe sepsis and septic shock.
Initial emergency department diagnosis and management of adult patients with severe sepsis and septic shock.
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DOI：
10.1186/1757-7241-20-41
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发表时间：
2012-06-27
期刊：
影响因子：
--
通讯作者：
Gaieski DF
中科院分区：
文献类型：
--
作者：
Perman SM;Goyal M;Gaieski DF
严重脓毒症是一种医疗紧急情况，影响全世界多达1800万人，仅北美每年的发病率就有75万。严重败血症患者的死亡率在28-50%之间。脓毒症是一种时间危重的疾病，需要早期识别和及时干预，以改善结果。这一观察结果提高了急救医学领域的认识和教育；它还导致在患者管理过程的早期实施关键干预措施，特别是早期目标导向治疗，并迅速给予适当的抗微生物药物。这篇综述首先简要概述了脓毒症的病理生理学，然后阐述了脓毒症患者ED识别和复苏的基本临床方面。
Severe sepsis is a medical emergency affecting up to 18 million individuals world wide, with an annual incidence of 750,000 in North America alone. Mortality ranges between 28-50% of those individuals stricken by severe sepsis. Sepsis is a time critical illness, requiring early identification and prompt intervention in order to improve outcomes. This observation has led to increased awareness and education in the field of Emergency Medicine; it has also led to the implementation of critical interventions early in the course of patient management, specifically Early-Goal Directed Therapy, and rapid administration of appropriate antimicrobials. This review begins with a brief summary of the pathophysiology of sepsis, and then addresses the fundamental clinical aspects of ED identification and resuscitation of the septic patient.
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