Myocardial adaptation to endurance exercise training in diabetic rats.
Myocardial adaptation to endurance exercise training in diabetic rats.
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糖尿病大鼠心肌对耐力运动训练的适应。
DOI：
10.1152/ajpregu.1987.252.6.r1073
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Tow,JP
中科院分区：
文献类型：
--
作者：
Paulson,DJ;Kopp,SJ;Peace,DG;Tow,JP
本研究的目的是确定运动训练是否能预防糖尿病大鼠心脏泵功能的进行性下降。研究分为四组：久坐对照组、训练对照组、久坐糖尿病患者和训练糖尿病患者。经训练的大鼠在诱导糖尿病前适应跑步机，其中一半的组注射链脲佐菌素（50 mg/kg）。然后，持续时间、速度和等级逐渐增加，直到训练大鼠能以27米/分钟、5%等级的速度跑60分钟（第8周）。在不同左心房充盈压力和含有体内葡萄糖和脂肪酸浓度的缓冲液下灌注的离体工作心脏中，测量心输出量和功。久坐不动的糖尿病大鼠体重降低，血糖、甘油三酯和胆固醇升高。糖尿病大鼠的运动训练降低了血浆甘油三酯水平。在训练对照组和训练糖尿病组中，训练显著增加了足底肌肉细胞色素氧化酶活性。在正常或糖尿病底物条件下，久坐的糖尿病大鼠心脏泵功能受损，但糖尿病条件下的损害更大。对糖尿病大鼠进行训练可以防止这种抑郁。久坐糖尿病大鼠心肌肉碱含量降低。运动训练增加了对照组和糖尿病大鼠的肉碱含量。该训练方案不影响训练对照组的心泵功能。这些结果提示运动训练可以限制糖尿病相关的心肌收缩功能障碍。
The purpose of this study was to determine whether exercise training would prevent the progressive functional decline in pump function of hearts from diabetic rats. Four groups were studied: sedentary control, trained control, sedentary diabetic, and trained diabetic. Trained rats were adapted to the treadmill prior to induction of diabetes in half of the group streptozotocin injected (50 mg/kg). Thereafter the duration, speed, and grade were then progressively increased until the trained rats could run for 60 min at 27 m/min, 5% grade (wk 8). Cardiac output and work were measured in isolated working hearts perfused at various left atrial filling pressures and with buffer containing the concentrations of glucose and fatty acids found in vivo. Sedentary diabetic rats had lowered body weight, elevated plasma glucose, triacylglycerol, and cholesterol. Exercise training of diabetic rats lowered plasma triacylglycerol levels. Training increased plantaris muscle cytochrome oxidase activity significantly in both the trained control and trained diabetic groups. Cardiac pump function was impaired in hearts from the sedentary diabetic rats perfused with either normal or diabetic substrate conditions, but the impairment was larger under diabetic conditions. Training of diabetic rats prevented this depression. Myocardial carnitine content was decreased in hearts from sedentary diabetic rats. Exercise training increased carnitine content in both control and diabetic rats. This training protocol did not affect cardiac pump function of the trained control group. These results suggest that exercise training may limit the myocardial contractile dysfunction associated with diabetes mellitus.
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通过磷 31 NMR 和化学提取研究了离体灌注糖尿病大鼠心脏中脂质介导的正常能量代谢损伤。
DOI：
--
发表时间：
1984
期刊：
Biochimica et Biophysica Acta
影响因子：
--
作者：
G. Pieper;J. M. Salhany;W. Murray;S. Wu;R. S. Eliot
通讯作者：
R. S. Eliot
胰岛素或肉碱治疗的糖尿病大鼠的心脏肌浆网功能。
DOI：
10.1152/ajpheart.1983.245.6.h969
发表时间：
1983
期刊：
The American journal of physiology
影响因子：
--
作者：
G. Lopaschuk;A. G. Tahiliani;R. Vadlamudi;S. Katz;J. McNeill
通讯作者：
J. McNeill
运动大鼠冠状血管储备的早期增加与心脏肥大无关。
DOI：
10.1152/jappl.1985.59.6.1861
发表时间：
1985
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Buttrick,PM;Levite,HA;Schaible,TF;Ciambrone,G;Scheuer,J
通讯作者：
Scheuer,J
慢性游泳可逆转高血压大鼠的心脏功能障碍和肌球蛋白异常。
DOI：
10.1152/jappl.1986.60.4.1435
发表时间：
1986
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Schaible,TF;Malhotra,A;Ciambrone,GJ;Scheuer,J
通讯作者：
Scheuer,J
DOI：
10.1016/s0735-1097(84)80207-7
发表时间：
1984-01-01
影响因子：
24
作者：
MILDENBERGER, RR;BARSHLOMO, B;MCLAUGHLIN, PR
通讯作者：
MCLAUGHLIN, PR