Isolation of human immunodeficiency virus from genital ulcers in Nairobi prostitutes.
Isolation of human immunodeficiency virus from genital ulcers in Nairobi prostitutes.
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从内罗毕妓女的生殖器溃疡中分离出人类免疫缺陷病毒。
DOI:
10.1093/infdis/160.3.380
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发表时间:
1989
期刊:
影响因子:
--
通讯作者:
Corey,L
中科院分区:
文献类型:
--
作者:
Kreiss,JK;Coombs,R;Plummer,F;Holmes,KK;Nikora,B;Cameron,W;Ngugi,E;NdinyaAchola,JO;Corey,L
Recent epidemiologic studies have implicated genital/anorectal ulcer disease as an important cofactor for acquisition and transmission of human immunodeficiency virus (HIV) during sexual intercourse. To better understand the mechanism for the association between genital ulcers and HIV, exudates from 62 genital ulcers of 56 HIV-seropositive prostitutes in Nairobi (Kenya) were cultured for HIV. Twenty-six ulcer cultures could not be evaluated for the presence of HIV because of bacterial or fungal contamination. HIV was isolated from 4 (11%) of the 36 remaining uncontaminated ulcer cultures (2 introital, 1 vaginal, and 1 cervical) from 4 separate women. HIV was isolated from the cervical os from only 2 of the 4 women. HIV p24 antigen was detected in exudate from 1 of the 4 culture-positive ulcers and 0 of 32 culture-negative ulcers. Genital ulcers in seropositive patients should be regarded as potential sources of HIV, which could be important in transmission of HIV during intercourse. Public health measures aimed at controlling sexually transmitted genital ulcer diseases should be an integral part of acquired immunodeficiency syndrome (AIDS) prevention programs.
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DOI:
10.1152/ajpendo.1983.244.5.e435
发表时间:
1983
期刊:
The American journal of physiology
影响因子:
--
作者:
LaBarbera,AR;Fisher,AE
通讯作者:
Fisher,AE
影响因子:
4
作者:
K. E. Hudson;S. Hillier
通讯作者:
S. Hillier
影响因子:
4.8
作者:
Lino,J;Baranao,S;Hammond,JM
通讯作者:
Hammond,JM
影响因子:
3.6
作者:
C. Rani;K. Nordenström;E. Norjavaara;K. Ahrén
通讯作者:
K. Ahrén
DOI:
--
发表时间:
1985
期刊:
Journal of Steroid Biochemistry
影响因子:
--
作者:
P. Silberzahn;G. Almahbobi;L. Dehennin;A. Merouane
通讯作者:
A. Merouane