Screening for depression in chronic obstructive pulmonary disease.
Screening for depression in chronic obstructive pulmonary disease.
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DOI：
10.3109/15412550903341463
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发表时间：
2009-12
期刊：
影响因子：
2.2
通讯作者：
Katz PP
中科院分区：
文献类型：
--
作者：
Julian LJ;Gregorich SE;Earnest G;Eisner MD;Chen H;Blanc PD;Yelin EH;Katz PP
抑郁症和慢性阻塞性肺疾病（COPD）是致残的主要原因。识别有抑郁风险的COPD患者将有助于减轻一种重要的合并症，这种合并症赋予了不良预后的额外风险。本研究的目的是确定一个简短的筛查措施，15项老年抑郁量表（GDS-15）在检测COPD患者情绪障碍方面的效用。这是一项对188名COPD患者的横断面研究，按年龄（65岁及以上与65岁以下）和COPD严重程度分层，使用全球慢性阻塞性肺疾病倡议（GOLD）分期。使用阈值选择方法经验推导筛选切点，并估计受试者工作特征（ROC）曲线。GDS-15被用作一种筛选措施，使用“金标准”标准化结构化临床访谈来确定重性抑郁症（MDD）或其他情绪障碍的诊断。在188名COPD患者中，25%符合任何情绪障碍的标准，11%符合重度抑郁症的标准。最佳阈值估计表明GDS cut评分为5，这在检测MDD方面产生了足够的灵敏度和特异性（分别为81%和87%），并正确分类了86%的参与者。为了检测任何情绪障碍的存在，建议cut评分为4分，敏感性和特异性分别为67%和82%；正确分类79%。这些结果表明，情绪障碍在COPD患者中相对常见。GDS-15是一种有用的筛查措施，可以识别有抑郁症风险的患者。
Depression and chronic obstructive pulmonary disease (COPD) are major causes of disability. Identifying COPD patients at risk for depression would facilitate the alleviation of an important comorbidity conferring additional risk for poor outcomes. The purpose of this study was to determine the utility of a brief screening measure, the 15-item Geriatric Depression Scale (GDS-15), in detecting the mood disorders in persons with COPD. This is a cross-sectional study of 188 persons with COPD, stratified by age (65 and older versus less than 65) and COPD severity using Global Initiative for Chronic Obstructive Lung Disease (GOLD) staging. Screening cut-points were empirically derived using threshold selection methods and receiver operating characteristic (ROC) curves were estimated. The GDS-15 was used as a screening measure and diagnoses of Major Depressive Disorder (MDD) or other mood disorders were determined using a “gold standard” standardized structured clinical interview. Of the 188 persons with COPD, 25% met criteria for any mood disorder and 11% met criteria for MDD. Optimal threshold estimations suggested a GDS cut score of 5, which yielded adequate sensitivity and specificity in detecting MDD (81% and 87%, respectively) and correctly classified 86% of participants. To detect the presence of any mood disorder, a cut score of 4 was suggested yielding sensitivity and specificity of 67% and 82%, respectively; correctly classifying 79%. These results suggest that mood disorders are relatively common among persons with COPD. The GDS-15 is a useful screening measure to identify patients at risk for depression.
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影响因子：
--
作者：
ADSHEAD, F;CODY, DD;PITT, B
通讯作者：
PITT, B
影响因子：
120.7
作者：
Jemal, A;Ward, E;Thun, M
通讯作者：
Thun, M
影响因子：
11
作者：
Houeto, JL;Mesnage, V;Agid, Y
通讯作者：
Agid, Y
DOI：
10.3132/pcrj.2007.00048
发表时间：
2007-08-01
期刊：
Primary care respiratory journal : journal of the General Practice Airways Group
影响因子：
--
作者：
Ahmed, Kamran;Kelshiker, Ashok;Jenner, Christopher
通讯作者：
Jenner, Christopher
影响因子：
120.7
作者：
JOHNSON, J;WEISSMAN, MM;KLERMAN, GL
通讯作者：
KLERMAN, GL