Dual transplantation of human neural stem cells into cervical and lumbar cord ameliorates motor neuron disease in SOD1 transgenic rats.
Dual transplantation of human neural stem cells into cervical and lumbar cord ameliorates motor neuron disease in SOD1 transgenic rats.
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DOI：
10.1016/j.neulet.2011.03.017
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发表时间：
2011-05-02
影响因子：
2.5
通讯作者：
Koliatsos VE
中科院分区：
文献类型：
--
作者：
Xu L;Shen P;Hazel T;Johe K;Koliatsos VE
干细胞为运动神经元疾病的细胞疗法提供了新的来源，最近已进入临床试验。在本研究中，我们将人神经干细胞（NSCs）移植到SOD G93 A大鼠的腰（L4-L5）和颈（C4-C5）突起的前角，以测试双移植范式的可行性和一般疗效，该范式涉及前肢、后肢和呼吸器官的几个肌肉群。移植是在运动神经元疾病发作之前进行的。与接受死亡神经干细胞移植的动物（作为对照）相比，在两个脊髓水平移植活神经干细胞的大鼠寿命延长了17天。与对照动物相比，双重移植动物的疾病发作延迟了10天。与对照组相比，神经干细胞移植动物的疾病持续时间延长了7天。我们的研究结果支持神经干细胞移植在多个脊髓水平的潜力，作为未来的运动神经元疾病的细胞治疗。
Stem cells provide novel sources of cell therapies for motor neuron disease that have recently entered clinical trials. In the present study, we transplanted human neural stem cells (NSCs) into the ventral horn of both the lumbar (L4–L5) and cervical (C4–C5) protuberance of SOD G93A rats, in an effort to test the feasibility and general efficacy of a dual grafting paradigm addressing several muscle groups in the front limbs, hind limbs and the respiratory apparatus. Transplantation was done prior to the onset of motor neuron disease. Compared with animals that had received dead NSC grafts (serving as controls), rats with live NSCs grafted at the two spinal levels lived 17 days longer. Disease onset in dually grafted animals was delayed by 10 days compared to control animals. Disease duration in NSC-grafted animals was longer by 7 days compared to controls. Our results support the potential of NSC grafts at multiple levels of spinal cord as future cellular therapy for motor neuron disease.
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