Immune cell-lipoprotein imbalance as a marker for early diagnosis of non-small cell lung cancer metastasis.
Immune cell-lipoprotein imbalance as a marker for early diagnosis of non-small cell lung cancer metastasis.
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免疫细胞脂蛋白失衡作为非小细胞肺癌转移早期诊断的标志物
DOI：
10.3389/fonc.2022.942964
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发表时间：
2022
影响因子：
4.7
通讯作者：
Quan, Wenqian
中科院分区：
文献类型：
--
作者：
Zhang, Wei;Wang, Weiwei;Wu, Junlu;Tian, Jiale;Yan, Wenhui;Yuan, Yi;Yao, Yiwen;Shang, Anquan;Quan, Wenqian
肺癌转移的分子机制和进化模式尚不清楚，缺乏有效的转移早期诊断指标。对同济大学同济医院2021年收治的117例原发非小细胞肺癌(NSCLC)患者进行回顾性分析，其中有肿瘤转移的患者93例为转移组。24例无转移患者为无转移组。比较两组患者各项指标的差异及不同TNM分期的表达水平。本研究旨在评价血液相关指标中性粒细胞/淋巴细胞(NLR)、淋巴细胞/单核细胞(LMR)、高密度脂蛋白/中性粒细胞(HNR)、高密度脂蛋白/单核细胞(HMR)及其联合检测对非小细胞肺癌转移的早期诊断价值和临床净效益。结果发现，转移性非小细胞肺癌NLR水平高于非转移性NSCLC，而LMR、HNR和HMR水平低于非转移性NSCLC。不同TNM分期患者的NLR、LMR、HNR和HMR水平显示，NLR水平随着TNM分期的升高而升高，而LMR、HNR和HMR水平则呈下降趋势。与单独试验相比，4项联合试验的阈值概率范围更大，总体临床受益率更高。提示NLR、LMR、HNR和HMR对NSCLC转移有较好的诊断价值。本研究为研究NSCLC转移前免疫细胞和脂代谢相关蛋白重塑微环境的机制提供了临床基础。
The underlying molecular mechanisms and evolutionary patterns of lung cancer metastasis remain unclear, resulting in a lack of effective indicators for early diagnosis of metastasis. We retrospectively analyzed 117 patients with primary non-small cell lung cancer (NSCLC) admitted to Tongji Hospital of Tongji University in 2021, of which 93 patients with tumor metastasis were set as the metastasis group. 24 patients without metastasis were set as the non-metastasis group. The differences of each index in the two groups of patients and the expression levels in different TNM stages were compared. This study intends to evaluate the diagnostic value and net clinical benefit of common blood-related indicators Neutrophil/lymphocyte (NLR), lymphocyte/monocyte (LMR), High density lipoprotein/neutrophil (HNR), High density lipoprotein/monocyte (HMR) and combined assays in NSCLC metastasis for the early diagnosis of patients with NSCLC metastasis. It was found that the level of NLR was higher in metastatic NSCLC than non-metastatic, but the level of LMR, HNR and HMR was lower. The levels of NLR, LMR, HNR and HMR in patients with different TNM stages showed that NLR levels increased with TNM stage, while LMR, HNR and HMR levels decreased. The threshold probability range of the 4 combined tests was greater and the overall clinical benefit rate was higher compared to the individual tests. Our findings suggest that NLR, LMR, HNR and HMR have better diagnostic value for NSCLC metastasis. This study provides a clinical basis for investigating the mechanisms by which immune cells and lipid metabolism-related proteins remodel the microenvironment prior to NSCLC metastasis.
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影响因子：
--
作者：
Qian C;Dai N;Xu M;Luo H;Feng Y;Zhang M;Chen R;Wang D
通讯作者：
Wang D
影响因子：
3.7
作者：
Stratmann JA;Lacko R;Ballo O;Shaid S;Gleiber W;Vehreschild MJGT;Wichelhaus T;Reinheimer C;Göttig S;Kempf VAJ;Kleine P;Stera S;Brandts C;Sebastian M;Koschade S
通讯作者：
Koschade S
DOI：
10.5761/atcs.oa.19-00315
发表时间：
2020-10-21
期刊：
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
影响因子：
--
作者：
Shoji F;Kozuma Y;Toyokawa G;Yamazaki K;Takeo S
通讯作者：
Takeo S
影响因子：
4.7
作者：
Yalon, Michal;Toren, Amos;Mehrian-Shai, Ruty
通讯作者：
Mehrian-Shai, Ruty
影响因子：
3.8
作者：
Chen, Lin;Qian, Jiawen;Chen, Fa
通讯作者：
Chen, Fa