Engineering design and molecular dynamics of mucoadhesive drug delivery systems as targeting agents.
Engineering design and molecular dynamics of mucoadhesive drug delivery systems as targeting agents.
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DOI：
10.1016/j.ejpb.2008.09.022
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Peppas NA
中科院分区：
文献类型：
--
作者：
Serra L;Doménech J;Peppas NA
这篇综述的目的是对黏附生物材料的微颗粒和纳米颗粒作用的链动力学进行批判性分析。使用生物粘合剂控制的药物递送装置的目的是延长其在特定递送部位的停留时间，从而增强药物吸收过程。这些黏附装置可以在吸收过程中保护药物，并在药物到达递送地点的途中保护药物。近年来黏附生物材料研究的重点是黏附促进剂的使用，它可以增强合成聚合物与黏液之间的黏附。使用粘合促进剂，如线性或系留聚合物链是粘合扩散特性的自然结果。黏附很大程度上取决于用于控释应用的合成聚合物凝胶的结构。
The goal of this critical review is to provide a critical analysis of the chain dynamics responsible for the action of micro- and nanoparticles of mucoadhesive biomaterials. The objective of using bioadhesive controlled drug delivery devices is to prolong their residence at a specific site of delivery, thus enhancing the drug absorption process. These mucoadhesive devices can protect the drug during the absorption process in addition to protecting it on its route to the delivery site. The major emphasis of recent research on mucoadhesive biomaterials has been on the use of adhesion promoters, which would enhance the adhesion between synthetic polymers and mucus. The use of adhesion promoters such as linear or tethered polymer chains is a natural result of the diffusional characteristics of adhesion. Mucoadhesion depends largely on the structure of the synthetic polymer gels used in controlled release applications.
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影响因子：
4.6
作者：
Hägerström, H;Edsman, K
通讯作者：
Edsman, K
影响因子：
4.6
作者：
Kim, B;Peppas, NA
通讯作者：
Peppas, NA
影响因子：
11.2
作者：
Fiebrig, I;Harding, SE;Davis, SS
通讯作者：
Davis, SS
影响因子：
4.4
作者：
Huang, YB;Szleifer, I;Peppas, NA
通讯作者：
Peppas, NA
影响因子：
3.7
作者：
HASSAN, EE;GALLO, JM
通讯作者：
GALLO, JM