Histopathology of thymectomy specimens from the MGTX-trial: Entropy analysis as strategy to quantify spatial heterogeneity of lymphoid follicle and fat distribution.
Histopathology of thymectomy specimens from the MGTX-trial: Entropy analysis as strategy to quantify spatial heterogeneity of lymphoid follicle and fat distribution.
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DOI：
10.1371/journal.pone.0197435
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Marx A
中科院分区：
文献类型：
--
作者：
Weis CA;Aban IB;Cutter G;Kaminski HJ;Scharff C;Grießmann BW;Deligianni M;Kayser K;Wolfe GI;Ströbel P;Marx A
The thymectomy specimens from the “thymectomy trial in non-thymomatous myasthenia gravis patients receiving prednisone therapy” (MGTX) underwent rigid and comprehensive work-up, which permits analysis of the spatial distribution of histological and immunohistological features. This analysis revealed strong intra- and inter-case variability. While many histological features (e.g. median percent fat content among different specimens) can easily be correlated with clinical parameters, intra-case spatial variability of histological features has yet defied quantification and statistical evaluation. To overcome this gap in digital pathology, we here propose intra-case entropy of measured histological features in all available slides of a given thymectomy specimen as a quantitative marker of spatial histological heterogeneity. Calculation of entropy led to one value per specimen and histological feature. Through these ‘entropy values’ the so far neglected degree of spatial histological heterogeneity could be fed into statistical analyses, extending the scope of clinico-pathological correlations.
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影响因子：
19.7
作者：
Kim, Jae-Hun;Ko, Eun Sook;Nam, Seok Jin
通讯作者：
Nam, Seok Jin
影响因子：
--
作者：
SHANNON, CE
通讯作者：
SHANNON, CE
DOI：
10.1111/j.1749-6632.1998.tb11015.x
发表时间：
1998-01-01
期刊：
MYASTHENIA GRAVIS AND RELATED DISEASES
影响因子：
--
作者：
Barohn, RJ;McIntire, D;Bryan, WW
通讯作者：
Bryan, WW
DOI：
10.1111/j.1749-6632.2012.06799.x
发表时间：
2012-01-01
期刊：
MYASTHENIA GRAVIS AND RELATED DISORDERS II
影响因子：
--
作者：
Marx, Alexander;Pfister, Frederik;Stroebel, Philipp
通讯作者：
Stroebel, Philipp
影响因子：
2.6
作者：
Besusparis J;Plancoulaine B;Rasmusson A;Augulis R;Green AR;Ellis IO;Laurinaviciene A;Herlin P;Laurinavicius A
通讯作者：
Laurinavicius A