Clonal hematopoiesis: Mutation-specific adaptation to environmental change.
Clonal hematopoiesis: Mutation-specific adaptation to environmental change.
复制标题
克隆造血：突变特异性适应环境变化。
DOI：
10.1016/j.stem.2022.05.006
复制
发表时间：
2022-06-02
期刊：
影响因子：
23.9
通讯作者：
King, Katherine Y.
中科院分区：
文献类型：
--
作者：
Florez, Marcus A.;Tran, Brandon T.;Wathan, Trisha K.;DeGregori, James;Pietras, Eric M.;King, Katherine Y.
Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion of genetically variant hematopoietic cells that increases exponentially with age and is associated with increased risks of cancers, cardiovascular disease, and other maladies. Here we discuss how environmental contexts associated with CHIP, such as old age, infections, chemotherapy, or cigarette smoking, alter tissue microenvironments to facilitate the selection and expansion of specific CHIP mutant clones. Further, we consider major remaining gaps in knowledge, including intrinsic effects, clone size thresholds and factors affecting clonal competition, that will determine future application of this field in transplant and preventive medicine.
登录
查看更多内容
影响因子：
30.8
作者：
Busque L;Patel JP;Figueroa ME;Vasanthakumar A;Provost S;Hamilou Z;Mollica L;Li J;Viale A;Heguy A;Hassimi M;Socci N;Bhatt PK;Gonen M;Mason CE;Melnick A;Godley LA;Brennan CW;Abdel-Wahab O;Levine RL
通讯作者：
Levine RL
在健康个体中预测急性髓样白血病的风险。
影响因子：
64.8
作者：
Abelson S;Collord G;Ng SWK;Weissbrod O;Mendelson Cohen N;Niemeyer E;Barda N;Zuzarte PC;Heisler L;Sundaravadanam Y;Luben R;Hayat S;Wang TT;Zhao Z;Cirlan I;Pugh TJ;Soave D;Ng K;Latimer C;Hardy C;Raine K;Jones D;Hoult D;Britten A;McPherson JD;Johansson M;Mbabaali F;Eagles J;Miller JK;Pasternack D;Timms L;Krzyzanowski P;Awadalla P;Costa R;Segal E;Bratman SV;Beer P;Behjati S;Martincorena I;Wang JCY;Bowles KM;Quirós JR;Karakatsani A;La Vecchia C;Trichopoulou A;Salamanca-Fernández E;Huerta JM;Barricarte A;Travis RC;Tumino R;Masala G;Boeing H;Panico S;Kaaks R;Krämer A;Sieri S;Riboli E;Vineis P;Foll M;McKay J;Polidoro S;Sala N;Khaw KT;Vermeulen R;Campbell PJ;Papaemmanuil E;Minden MD;Tanay A;Balicer RD;Wareham NJ;Gerstung M;Dick JE;Brennan P;Vassiliou GS;Shlush LI
通讯作者：
Shlush LI
影响因子：
15.9
作者：
Cai, Zhigang;Lu, Xiaoyu;Kapur, Reuben
通讯作者：
Kapur, Reuben
影响因子：
6.2
作者：
Brunner, Andrew M.;Neuberg, Donna S.;Fathi, Amir T.
通讯作者：
Fathi, Amir T.
老化的造血干细胞室中 DNA 损伤的积累。
影响因子：
3.6
作者：
Beerman I
通讯作者：
Beerman I