A pilot study of regional perfusion and oxygenation in calf muscles of individuals with diabetes with a noninvasive measure.
A pilot study of regional perfusion and oxygenation in calf muscles of individuals with diabetes with a noninvasive measure.
复制标题
采用无创措施对糖尿病患者小腿肌肉局部灌注和氧合进行的初步研究。
DOI：
10.1016/j.jvs.2013.07.115
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发表时间：
2014
影响因子：
4.3
通讯作者：
Mueller,MichaelJ
中科院分区：
文献类型：
--
作者：
Zheng,Jie;Hasting,MaryK;Zhang,Xiaodong;Coggan,Andrew;An,Hongyu;Snozek,Darrah;Curci,John;Mueller,MichaelJ
ObjectiveAssessment alterations in the regional perfusion and oxygenation of the calf muscle in individuals with diabetes.Methods与糖尿病患者（n = 5）和非糖尿病患者（n = 6）进行了研究。骨骼肌灌注，氧提取分数，和耗氧率通过新开发的非对比磁共振成像（MRI）技术进行了测量。受试者仰卧在MRI台上，脚牢牢地绑在定制的等长运动装置上。在休息和等长跖屈muscle contraction.ResultsIndividuals没有糖尿病的人有高达10倍的增加肌肉灌注，25%的海拔在肌肉氧提取分数，和12倍的增加在小腿的氧消耗率在跖屈等长收缩。在糖尿病患者中，这些参数分别仅增加了6倍、2%和6倍。运动耗氧率与血液HbA1c水平呈负相关（r2= 0.91）。ConclusionsThis是第一个研究，以量化区域骨骼肌氧合在糖尿病患者使用非对比MRI和值得进一步研究。运动过程中灌注和氧合的衰减可能对了解糖尿病下肢并发症有意义。
ObjectiveTo assess alterations in the regional perfusion and oxygenation of the calf muscles in individuals with diabetes.MethodsAge-matched individuals with (n = 5) and without diabetes (n = 6) were investigated. Skeletal muscle perfusion, oxygen extraction fraction, and oxygen consumption rate were measured by newly developed noncontrast magnetic resonance imaging (MRI) techniques. The subjects lay supine on the MRI table with their foot firmly strapped to a custom-built isometric exercise device. The measurements were performed at rest and during an isometric plantar flexion muscle contraction.ResultsIndividuals without diabetes had up to a 10-fold increase in muscle perfusion, 25% elevation in muscle oxygen extraction fraction, and a 12-fold increase in oxygen consumption rate in the calf during the plantar flexion isometric contraction. In patients with diabetes, the increases in these parameters were only up to sixfold, 2%, and sixfold, respectively. Exercise oxygen consumption rate was inversely associated with blood HbA1c levels (r2= .91).ConclusionsThis is the first study to quantify regional skeletal muscle oxygenation in patients with diabetes using noncontrast MRI and warrants additional study. Attenuation of perfusion and oxygenation during exercise may have implications for understanding diabetic complications in the lower extremities.
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影响因子：
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作者：
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DOI：
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