Metabolic regulation by biomaterials in osteoblast.
Metabolic regulation by biomaterials in osteoblast.
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成骨细胞中生物材料的代谢调节。
DOI：
10.3389/fbioe.2023.1184463
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发表时间：
2023
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
高能量创伤、感染或病理性骨折导致的骨缺损的修复仍然是医学领域的挑战。参与代谢调控的生物材料的发展为这一问题提供了一个有希望的解决方案，并已成为再生工程的一个突出研究领域。虽然最近对细胞代谢的研究提高了我们对骨再生代谢调节的认识，但材料影响细胞内代谢的程度仍不清楚。本文就骨再生的机制、成骨细胞骨再生的代谢调控以及参与骨再生代谢调控的生物材料作一综述。此外，它介绍了如何材料，如促进有利的物理化学特性（例如，生物活性、适当的孔隙率和上级机械性能），结合外部刺激（例如，光热、电和磁刺激），并递送代谢调节剂（例如，金属离子、药物和肽等生物活性分子以及α酮戊二酸等调节代谢产物）可以影响细胞代谢并导致细胞状态变化。考虑到对细胞代谢调节的兴趣日益增长，先进材料有可能帮助更大的人群克服骨缺损。
The repair of bone defects resulting from high-energy trauma, infection, or pathological fracture remains a challenge in the field of medicine. The development of biomaterials involved in the metabolic regulation provides a promising solution to this problem and has emerged as a prominent research area in regenerative engineering. While recent research on cell metabolism has advanced our knowledge of metabolic regulation in bone regeneration, the extent to which materials affect intracellular metabolic remains unclear. This review provides a detailed discussion of the mechanisms of bone regeneration, an overview of metabolic regulation in bone regeneration in osteoblasts and biomaterials involved in the metabolic regulation for bone regeneration. Furthermore, it introduces how materials, such as promoting favorable physicochemical characteristics (e.g., bioactivity, appropriate porosity, and superior mechanical properties), incorporating external stimuli (e.g., photothermal, electrical, and magnetic stimulation), and delivering metabolic regulators (e.g., metal ions, bioactive molecules like drugs and peptides, and regulatory metabolites such as alpha ketoglutarate), can affect cell metabolism and lead to changes of cell state. Considering the growing interests in cell metabolic regulation, advanced materials have the potential to help a larger population in overcoming bone defects.
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影响因子：
7.5
作者：
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影响因子：
5.5
作者：
Barrett, Devin G.;Yousaf, Muhammad N.
通讯作者：
Yousaf, Muhammad N.
影响因子：
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Franceschi, Renny T.
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Zhang MZ
影响因子：
5.2
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通讯作者：
Reincke M