Microcarriers in application for cartilage tissue engineering: Recent progress and challenges.
Microcarriers in application for cartilage tissue engineering: Recent progress and challenges.
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DOI：
10.1016/j.bioactmat.2022.01.033
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发表时间：
2022-11
影响因子：
18.9
通讯作者：
Zhang MZ
中科院分区：
文献类型：
--
作者：
Ding SL;Liu X;Zhao XY;Wang KT;Xiong W;Gao ZL;Sun CY;Jia MX;Li C;Gu Q;Zhang MZ
在过去的几十年里，在临床规模上成功地再生软骨组织一直是一个巨大的挑战。微载体（MCs）通常用于细胞和药物的递送，在医学领域得到了广泛的研究，尤其是软骨组织工程（TE）。值得注意的是，微载体系统为调节细胞表型和微组织成熟提供了一种有吸引力的方法，它们也可以作为强大的注射载体，并与软骨再生的新技术相结合。本文介绍了制备各种类型微载体的典型方法，并讨论了适合微载体的材料。此外，我们还重点介绍了微载流子的最新应用进展和一般设计原则。最后，总结了基于微载体的医疗应用系统目前面临的挑战和前景。综上所述，本文为软骨TE微载体的合理设计和应用提供了全面、系统的指导。微载体在关节软骨缺损修复和软骨再生中的应用。微载体是一种三维培养平台，在细胞培养、扩增、递送、生物学研究建模和医学植入等生物和生物医学应用中已被用作支架，并可与注射和生物打印技术相结合，具有潜在的临床应用价值。本文综述了微载体的制备技术及其在软骨修复中的应用。讨论了软骨组织工程中微载体的合适材料和设计原则。展望了微载体领域的发展前景和面临的挑战。
Successful regeneration of cartilage tissue at a clinical scale has been a tremendous challenge in the past decades. Microcarriers (MCs), usually used for cell and drug delivery, have been studied broadly across a wide range of medical fields, especially the cartilage tissue engineering (TE). Notably, microcarrier systems provide an attractive method for regulating cell phenotype and microtissue maturations, they also serve as powerful injectable carriers and are combined with new technologies for cartilage regeneration. In this review, we introduced the typical methods to fabricate various types of microcarriers and discussed the appropriate materials for microcarriers. Furthermore, we highlighted recent progress of applications and general design principle for microcarriers. Finally, we summarized the current challenges and promising prospects of microcarrier-based systems for medical applications. Overall, this review provides comprehensive and systematic guidelines for the rational design and applications of microcarriers in cartilage TE. Microcarriers applied in joints for the repair of cartilage defects and cartilage regeneration. Microcarriers are three-dimensional culture platform that have been applied as scaffolds in biological and biomedical applications such as cell culture, expansion, delivery, modeling for biological studies, and medical implants, and can be combined with injection and bioprinting techniques for potential clinical application. This review summarized fabrication techniques and cartilage repaired application of microcarriers. The appropriate materials and design principle for microcarriers in cartilage tissue engineering are discussed. Promising future perspectives and challenges in microcarriers fields are outlined.
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影响因子：
14
作者：
Balakrishnan, B;Jayakrishnan, A
通讯作者：
Jayakrishnan, A
影响因子：
3.8
作者：
Bodick N;Williamson T;Strand V;Senter B;Kelley S;Boyce R;Lightfoot-Dunn R
通讯作者：
Lightfoot-Dunn R
影响因子：
9.7
作者：
Antich, Cristina;de Vicente, Juan;Antonio Marchal, Juan
通讯作者：
Antonio Marchal, Juan
影响因子：
5.4
作者：
Bellich B;D'Agostino I;Semeraro S;Gamini A;Cesàro A
通讯作者：
Cesàro A
DOI：
10.1016/j.trsl.2013.11.003
发表时间：
2014-04
期刊：
Translational research : the journal of laboratory and clinical medicine
影响因子：
--
作者：
Brown BN;Badylak SF
通讯作者：
Badylak SF