MeiosisOnline: A Manually Curated Database for Tracking and Predicting Genes Associated With Meiosis.

MeiosisOnline: A Manually Curated Database for Tracking and Predicting Genes Associated With Meiosis.
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MeiosisOnline:手动管理的数据库,用于跟踪和预测与减数分裂相关的基因

DOI:
10.3389/fcell.2021.673073
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发表时间:
2021
影响因子:
5.5
通讯作者:
Zhang Y
Zhang Y
中科院分区:
生物学2区
文献类型:
--
作者:
Jiang X;Zhao D;Ali A;Xu B;Liu W;Wen J;Zhang H;Shi Q;Zhang Y

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减数分裂是配子发生的重要步骤,也是有性生殖生物的关键事件。据报道,成千上万的基因参与减数分裂。因此,科学家需要一个专业的数据库来快速了解这些基因的功能,并寻找在减数分裂中具有潜在作用的基因。在这里,我们开发了“MeiosisOnline”,这是一个可公开访问的全面数据库,包含减数分裂中已知的功能基因和潜在的候选基因(https://mcg.ustc.edu.cn/bsc/meiosis/index.html)。从文献资源中人工整理了2,052个减数分裂基因,并将其分为不同的类别。为减数分裂基因和预测的候选基因提供注释信息,包括基本信息、功能、蛋白质-蛋白质相互作用(PPI)和表达数据。另一方面,使用“Greed AUC Stepwise”算法预测165个小鼠基因为减数分裂中的潜在候选基因。因此,MeiosisOnline提供了减数分裂中实验验证和预测基因的最新和详细的信息。此外,MeiosisOnline的搜索工具和友好的界面将极大地帮助研究人员以一种简单有效的方式研究减数分裂。
Meiosis, an essential step in gametogenesis, is the key event in sexually reproducing organisms. Thousands of genes have been reported to be involved in meiosis. Therefore, a specialist database is much needed for scientists to know about the function of these genes quickly and to search for genes with potential roles in meiosis. Here, we developed “MeiosisOnline,” a publicly accessible, comprehensive database of known functional genes and potential candidates in meiosis (https://mcg.ustc.edu.cn/bsc/meiosis/index.html). A total of 2,052 meiotic genes were manually curated from literature resource and were classified into different categories. Annotation information was provided for both meiotic genes and predicted candidates, including basic information, function, protein–protein interaction (PPI), and expression data. On the other hand, 165 mouse genes were predicted as potential candidates in meiosis using the “Greed AUC Stepwise” algorithm. Thus, MeiosisOnline provides the most updated and detailed information of experimental verified and predicted genes in meiosis. Furthermore, the searching tools and friendly interface of MeiosisOnline will greatly help researchers in studying meiosis in an easy and efficient way.
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