Development of a dose-response model for porcine cysticercosis.
Development of a dose-response model for porcine cysticercosis.
复制标题
DOI：
10.1371/journal.pone.0264898
复制
发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Cysticercosis Working Group in Peru
中科院分区：
文献类型：
--
作者：
Andrade-Mogrovejo DA;Gonzales-Gustavson E;Ho-Palma AC;Prada JM;Bonnet G;Pizzitutti F;Gomez-Puerta LA;Arroyo G;O'Neal SE;Garcia HH;Guitian J;Gonzalez A;Cysticercosis Working Group in Peru
猪带绦虫是全世界获得性癫痫的重要病因，在亚洲、非洲和拉丁美洲仍然流行。尽管设计了感染实验来提高我们对该疾病的了解，但对这种寄生虫的传播仍然知之甚少，并且仍然缺乏对关键流行病学参数的估计，例如接触鸡蛋后人传猪的可能性。本文进行了系统综述，并分析了八只猪的感染实验，以描述出现包囊的可能性。这些实验包括不同的接种途径：摄入节片、卵和摄入卵的甲虫，以及将活化的甲球直接注射到颈动脉中。在这些实验中，使用了不同的感染剂量，并记录了每头猪体内和大脑中活的和退化的包囊的数量。评估了五种替代剂量反应模型（指数、逻辑、对数逻辑、精确和近似β-泊松）在描述观察到的包囊发育概率随接种剂量变化的准确性。针对三种类型囊肿（任何囊肿、仅存活囊肿和脑内囊肿）的存在分别开发了剂量反应模型，并考虑了四种接种方法（“节片”、“卵”、“甲虫”和“颈动脉”）中的每一种。精确的 β-泊松模型最适合三种类型囊肿和所有相关暴露途径的数据。然而，对某些暴露途径的观察太少，无法用任何模型可靠地定义剂量反应曲线。仅针对“卵”途径和结合了“节片”、“卵”和“甲虫”途径的合并“口服”途径，发现了足够宽的剂量范围和足够的样本量。该模型的估计参数值表明，低感染剂量足以导致 50% 的概率发生任何囊肿或可行的囊肿感染。尽管这是依赖于有限数据集的初步模型，但本手稿中描述的参数应有助于未来与猪绦虫传播相关的实验感染的设计，以及旨在通知控制的传播模拟模型的参数化。
Taenia solium is an important cause of acquired epilepsy worldwide and remains endemic in Asia, Africa, and Latin America. Transmission of this parasite is still poorly understood despite the design of infection experiments to improve our knowledge of the disease, with estimates for critical epidemiological parameters, such as the probability of human-to-pig infection after exposure to eggs, still lacking. In this paper, a systematic review was carried out and eight pig infection experiments were analyzed to describe the probability of developing cysts. These experiments included different pathways of inoculation: with ingestion of proglottids, eggs, and beetles that ingested eggs, and direct injection of activated oncospheres into the carotid artery. In these experiments, different infective doses were used, and the numbers of viable and degenerated cysts in the body and brain of each pig were registered. Five alternative dose-response models (exponential, logistic, log-logistic, and exact and approximate beta-Poisson) were assessed for their accuracy in describing the observed probabilities of cyst development as a function of the inoculation dose. Dose-response models were developed separately for the presence of three types of cysts (any, viable only, and cysts in the brain) and considered for each of the four inoculation methods (“Proglottids”, “Eggs”, “Beetles” and “Carotid”). The exact beta-Poisson model best fit the data for the three types of cysts and all relevant exposure pathways. However, observations for some exposure pathways were too scarce to reliably define a dose-response curve with any model. A wide enough range of doses and sufficient sample sizes was only found for the “Eggs” pathway and a merged “Oral” pathway combining the “Proglottids”, “Eggs” and “Beetles” pathways. Estimated parameter values from this model suggest that a low infective dose is sufficient to result in a 50% probability for the development of any cyst or for viable cyst infections. Although this is a preliminary model reliant on a limited dataset, the parameters described in this manuscript should contribute to the design of future experimental infections related to T. solium transmission, as well as the parameterization of simulation models of transmission aimed at informing control.
登录
查看更多内容
影响因子：
5.5
作者：
de Aluja, AS;Villalobos, NM;Sciutto, E
通讯作者：
Sciutto, E
影响因子：
--
作者：
Del Brutto OH
通讯作者：
Del Brutto OH
影响因子：
3.8
作者：
Skrip LA;Dermauw V;Dorny P;Ganaba R;Millogo A;Tarnagda Z;Carabin H
通讯作者：
Carabin H
DOI：
10.1590/s1984-29612014014
发表时间：
2014-03-01
期刊：
Revista Brasileira de Parasitologia Veterinária
影响因子：
--
作者：
Gomez-Puerta, Luis Antonio;Lopez-Urbina, Maria Teresa;Gonzalez, Armando Emiliano
通讯作者：
Gonzalez, Armando Emiliano
影响因子：
2.7
作者：
Gabriel, S.;Dorny, P.;Johansen, M. V.
通讯作者：
Johansen, M. V.