Hensen's node induces neural tissue in Xenopus ectoderm. Implications for the action of the organizer in neural induction.
Hensen's node induces neural tissue in Xenopus ectoderm. Implications for the action of the organizer in neural induction.
复制标题
亨森节点诱导爪蟾外胚层中的神经组织。
作者：
C. Kintner;J. Dodd
脊椎动物神经系统的发育是在两栖动物中通过外胚层和胚胎中称为组织者的区域之间的诱导作用而开始的。在鸡胚中，非洲爪哇和汉森结囊胚孔背唇的组织者组织移植到各自胚胎的异位部位时，具有相似的神经诱导特性。为了开始确定组织者诱导信号的性质以及它们是否在物种之间保守，我们检测了Hensen‘s节点在非洲爪哇外胚层中诱导神经组织的能力。我们发现，Hensen‘s结会在非洲爪哇外胚层中诱导出大量的神经组织。神经诱导在没有中胚层分化的情况下进行，并伴随着组织运动，这可能反映了无模板诱导。外胚层对Hensen‘s结节的反应能力在发育过程中比激活素-A或植物细胞诱导的能力延伸得晚得多，并且与轴向中胚层神经诱导的延伸能力相似。激活素-A和Hensen‘s Node的作用通过它们对锂处理的外胚层的影响而进一步区分。这些结果表明，神经诱导可以有效地响应来自组织者组织的诱导信号，这些信号阻止在原肠形成之前的阶段，并且这种早期囊胚的相互作用可能是脊椎动物胚胎神经诱导的重要组成部分。
The development of the vertebrate nervous system is initiated in amphibia by inductive interactions between ectoderm and a region of the embryo called the organizer. The organizer tissue in the dorsal lip of the blastopore of Xenopus and Hensen's node in chick embryos have similar neural inducing properties when transplanted into ectopic sites in their respective embryos. To begin to determine the nature of the inducing signals of the organizer and whether they are conserved across species we have examined the ability of Hensen's node to induce neural tissue in Xenopus ectoderm. We show that Hensen's node induces large amounts of neural tissue in Xenopus ectoderm. Neural induction proceeds in the absence of mesodermal differentiation and is accompanied by tissue movements which may reflect notoplate induction. The competence of the ectoderm to respond to Hensen's node extends much later in development than that to activin-A or to induction by vegetal cells, and parallels the extended competence to neural induction by axial mesoderm. The actions of activin-A and Hensen's node are further distinguished by their effects on lithium-treated ectoderm. These results suggest that neural induction can occur efficiently in response to inducing signals from organizer tissue arrested at a stage prior to gastrulation, and that such early interactions in the blastula may be an important component of neural induction in vertebrate embryos.
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DOI：
10.1242/dev.109.1.225
发表时间：
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期刊：
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DOI：
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发表时间：
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期刊：
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