Slippery Liquid-Like Solid Surfaces with Promising Antibiofilm Performance under Both Static and Flow Conditions.
Slippery Liquid-Like Solid Surfaces with Promising Antibiofilm Performance under Both Static and Flow Conditions.
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DOI：
10.1021/acsami.1c14533
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发表时间：
2022-02-09
影响因子：
9.5
通讯作者：
Chen, Jinju
中科院分区：
文献类型：
--
作者：
Zhu, Yufeng;McHale, Glen;Dawson, Jack;Armstrong, Steven;Wells, Gary;Han, Rui;Liu, Hongzhong;Vollmer, Waldemar;Stoodley, Paul;Jakubovics, Nicholas;Chen, Jinju
生物膜是从医学到工业再到环境等不同应用领域中一些最紧迫的全球性挑战的核心，并产生相当大的经济和社会影响。抗生物膜的基本假设是基底表面上的涂层是固体。光滑的液体注入的多孔表面的发明-一个连续的湿润滑涂层保留在固体表面上的毛细作用力-导致这受到挑战。然而，在发生流动的情况下，剪切应力可能耗尽润滑剂并影响抗生物膜性能。在这里，我们报告使用光滑的全憎共价附着液体（SOCAL）表面，它提供了一个表面涂层与短（约。4 nm）非交联的聚二甲基硅氧烷（PDMS）链保持液体表面性质，作为在来自流动的剪切应力下稳定的疏水膜策略。在静态和动态培养条件下7天后，与广泛使用的医用植入材料PDMS相比，该表面将关键生物膜形成病原体表皮葡萄球菌和铜绿假单胞菌的生物膜形成减少了3 - 4个数量级。在铜绿假单胞菌的整个动态培养期间，SOCAL显著优于典型的生物膜光滑表面[即，硅油中的溶胀PDMS（S-PDMS）]。我们已经揭示了S-PDMS在2-7天流动后发生显著的油损失，这与增加的接触角滞后（CAH）相关，表明光滑表面性质的降解和生物膜形成，而SOCAL在7天流动后具有稳定的CAH和可持续的生物膜性能。这种相关性的意义在于提供了一个有用的、易于测量的物理参数，作为长期耐候薄膜性能的指标。这种抗生物膜的液体状固体表面为医疗器械和其他生物膜发展存在问题的领域提供了一种新的生物膜策略。
Biofilms are central to some of the most urgent global challenges across diverse fields of application, from medicine to industries to the environment, and exert considerable economic and social impact. A fundamental assumption in anti-biofilms has been that the coating on a substrate surface is solid. The invention of slippery liquid-infused porous surfaces—a continuously wet lubricating coating retained on a solid surface by capillary forces—has led to this being challenged. However, in situations where flow occurs, shear stress may deplete the lubricant and affect the anti-biofilm performance. Here, we report on the use of slippery omniphobic covalently attached liquid (SOCAL) surfaces, which provide a surface coating with short (ca. 4 nm) non-cross-linked polydimethylsiloxane (PDMS) chains retaining liquid–surface properties, as an antibiofilm strategy stable under shear stress from flow. This surface reduced biofilm formation of the key biofilm-forming pathogens Staphylococcus epidermidis and Pseudomonas aeruginosa by three–four orders of magnitude compared to the widely used medical implant material PDMS after 7 days under static and dynamic culture conditions. Throughout the entire dynamic culture period of P. aeruginosa, SOCAL significantly outperformed a typical antibiofilm slippery surface [i.e., swollen PDMS in silicone oil (S-PDMS)]. We have revealed that significant oil loss occurred after 2–7 day flow for S-PDMS, which correlated to increased contact angle hysteresis (CAH), indicating a degradation of the slippery surface properties, and biofilm formation, while SOCAL has stable CAH and sustainable antibiofilm performance after 7 day flow. The significance of this correlation is to provide a useful easy-to-measure physical parameter as an indicator for long-term antibiofilm performance. This biofilm-resistant liquid-like solid surface offers a new antibiofilm strategy for applications in medical devices and other areas where biofilm development is problematic.
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DOI：
10.1021/acs.langmuir.0c02668
发表时间：
2020-12-15
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
Barrio-Zhang H;Ruiz-Gutiérrez É;Armstrong S;McHale G;Wells GG;Ledesma-Aguilar R
通讯作者：
Ledesma-Aguilar R
纳米结构的钛表面表现出对葡萄球菌生物膜形成的顽固性。
影响因子：
4.6
作者：
Cao Y;Su B;Chinnaraj S;Jana S;Bowen L;Charlton S;Duan P;Jakubovics NS;Chen J
通讯作者：
Chen J
影响因子：
3.9
作者：
Fadeeva, Elena;Truong, Vi Khanh;Ivanova, Elena P.
通讯作者：
Ivanova, Elena P.
影响因子：
4.6
作者：
Diu T;Faruqui N;Sjöström T;Lamarre B;Jenkinson HF;Su B;Ryadnov MG
通讯作者：
Ryadnov MG
DOI：
10.1016/0956-9618(94)80024-3
发表时间：
1994-10-01
期刊：
SEPARATIONS TECHNOLOGY
影响因子：
--
作者：
ELIMELECH, M
通讯作者：
ELIMELECH, M