Phase-contrast magnetic resonance imaging measurements in intracranial aneurysms in vivo of flow patterns, velocity fields, and wall shear stress: comparison with computational fluid dynamics.
Phase-contrast magnetic resonance imaging measurements in intracranial aneurysms in vivo of flow patterns, velocity fields, and wall shear stress: comparison with computational fluid dynamics.
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DOI：
10.1002/mrm.21861
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发表时间：
2009-02
影响因子：
3.3
通讯作者：
Saloner, David
中科院分区：
文献类型：
--
作者：
Boussel, Loic;Rayz, Vitaliy;Martin, Alastair;Acevedo-Bolton, Gabriel;Lawton, Michael T.;Higashida, Randall;Smith, Wade S.;Young, William L.;Saloner, David
关键词：
已知颅内动脉瘤的演变与血流动力学力相关，例如壁面剪切应力（WSS）和最大剪切应力（MSS）。这些参数的估计可以使用数值模拟（计算流体动力学- CFD）来执行，但是也可以使用具有速度矢量的三个分量中的每一个的编码的时间相关的3D相衬序列（7 D-MRV），利用MRI来直接测量。为了研究7 D-MRV在体内估计这些参数的准确性，与CFD相比，对3名患有颅内动脉瘤的患者进行了7 D-MRV和患者特定CFD建模。对两种技术之间的流态和速度分布、MSS和WSS进行了可视化和定量分析。两种技术之间的斯皮尔曼相关系数分别为0.56的速度场，0.48的MSS和0.59的WSS。可视化分析和Bland-Altman图显示流型和速度有很好的一致性，但MSS和WSS差异较大。总之，这些结果表明，体内7 D-MRV可用于测量速度流场并估计MSS和WSS，但目前无法提供最后两个参数的准确定量。
Evolution of intracranial aneurysms is known to be related to hemodynamic forces such as Wall Shear Stress (WSS) and Maximum Shear Stress (MSS). Estimation of these parameters can be performed using numerical simulations (computational fluid dynamics - CFD) but can also be directly measured with MRI using a time-dependent 3D phase-contrast sequence with encoding of each of the three components of the velocity vectors (7D-MRV). In order to study the accuracy of 7D-MRV in estimating these parameters in–vivo, in comparison with CFD, 7D-MRV and patient-specific CFD modeling was performed for three patients who had intracranial aneurysms. A visual and a quantitative analysis of the flow pattern and the distribution of velocities, MSS, and WSS were performed between the two techniques. Spearman's coefficients of correlation between the two techniques were 0.56 for the velocity field, 0.48 for MSS and 0.59 for WSS. Visual analysis and Bland-Altman plots showed a good agreement for flow pattern and velocities but large discrepancies for MSS and WSS. In conclusion, these results indicate that in-vivo 7D-MRV can be used to measure velocity flow fields and to estimate MSS and WSS but is not currently able to provide accurate quantification of these two last parameters.
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