Anatomy of hierarchy: feedforward and feedback pathways in macaque visual cortex.
Anatomy of hierarchy: feedforward and feedback pathways in macaque visual cortex.
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DOI：
10.1002/cne.23458
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发表时间：
2014-01-01
影响因子：
2.5
通讯作者：
Kennedy, Henry
中科院分区：
文献类型：
--
作者：
Markov, Nikola T.;Vezoli, Julien;Chameau, Pascal;Falchier, Arnaud;Quilodran, Rene;Huissoud, Cyril;Lamy, Camille;Misery, Pierre;Giroud, Pascale;Ullman, Shimon;Barone, Pascal;Dehay, Colette;Knoblauch, Kenneth;Kennedy, Henry
细胞体的层状位置和区域间连接的末端决定了皮层的层次结构组织，这一点已经得到了深入的研究。然而，我们对前馈（FF）和反馈（FB）通路的连接原理仍然只有初步的了解。逆行示踪剂的定量分析被用来扩展神经元层流分布的概念，即神经元相互连接的视觉区域提供了层次距离的指标（核上标记神经元的百分比[SLN]）。我们发现：1)SLN值约束了皮层层次模型，揭示了以前未被怀疑的区域关系；2) SLN反映了一种组合距离规则对区域间连接集的差分作用；3)粒上层包含高度分离的自底向上和自顶向下的流，两者都表现出点对点的连通性。这与颗粒内层形成对比，颗粒内层包含弥漫的自下而上和自上而下的流；4) FF和FB通路亲本神经元的细胞填充为区隔化提供了进一步的证据；5)与FB途径相比，FF途径具有更高的权重，跨越更少的层次，数量更少。综上所述，目前的结果表明，皮层的层次结构是建立在小颗粒上和小颗粒下的逆流之上的。这种分隔的双重逆流组织允许自下而上和自上而下方向上的点对点连接。
The laminar location of the cell bodies and terminals of interareal connections determines the hierarchical structural organization of the cortex and has been intensively studied. However, we still have only a rudimentary understanding of the connectional principles of feedforward (FF) and feedback (FB) pathways. Quantitative analysis of retrograde tracers was used to extend the notion that the laminar distribution of neurons interconnecting visual areas provides an index of hierarchical distance (percentage of supragranular labeled neurons [SLN]). We show that: 1) SLN values constrain models of cortical hierarchy, revealing previously unsuspected areal relations; 2) SLN reflects the operation of a combinatorial distance rule acting differentially on sets of connections between areas; 3) Supragranular layers contain highly segregated bottom-up and top-down streams, both of which exhibit point-to-point connectivity. This contrasts with the infragranular layers, which contain diffuse bottom-up and top-down streams; 4) Cell filling of the parent neurons of FF and FB pathways provides further evidence of compartmentalization; 5) FF pathways have higher weights, cross fewer hierarchical levels, and are less numerous than FB pathways. Taken together, the present results suggest that cortical hierarchies are built from supra- and infragranular counterstreams. This compartmentalized dual counterstream organization allows point-to-point connectivity in both bottom-up and top-down directions.
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影响因子：
16.2
作者：
Bosman CA;Schoffelen JM;Brunet N;Oostenveld R;Bastos AM;Womelsdorf T;Rubehn B;Stieglitz T;De Weerd P;Fries P
通讯作者：
Fries P
影响因子：
16.2
作者：
Bastos AM;Usrey WM;Adams RA;Mangun GR;Fries P;Friston KJ
通讯作者：
Friston KJ
DOI：
10.1073/pnas.1011284108
发表时间：
2011-07-05
影响因子：
11.1
作者：
Buffalo, Elizabeth A.;Fries, Pascal;Desimone, Robert
通讯作者：
Desimone, Robert
影响因子：
3.7
作者：
Batardière, A;Barone, P;Kennedy, H
通讯作者：
Kennedy, H
影响因子：
1.8
作者：
CRAGG, BG
通讯作者：
CRAGG, BG