Innate immune mechanisms to oral pathogens in oral mucosa of HIV-infected individuals.
Innate immune mechanisms to oral pathogens in oral mucosa of HIV-infected individuals.
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DOI：
10.1111/odi.13470
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发表时间：
2020-09
期刊：
影响因子：
3.8
通讯作者：
Naglik JR
中科院分区：
文献类型：
--
作者：
Weinberg A;Tugizov S;Pandiyan P;Jin G;Rakshit S;Vyakarnam A;Naglik JR
粘膜HIV传播的一个关键方面是HIV、局部环境和免疫细胞之间的相互作用。口腔粘膜由许多宿主细胞类型组成，包括上皮细胞、CD 4 + T细胞、树突状细胞和单核细胞/巨噬细胞，以及主要由细菌物种组成的多种微生物组。虽然口腔上皮是通过口腔-生殖器接触和哺乳婴儿暴露于艾滋病毒的第一个部位之一，但它在很大程度上被认为是通过尚不清楚的机制抵抗艾滋病毒传播的。HIV-1感染还与继发感染的易感性有关，如结核病和其他疾病，包括癌症。本综述讨论了2019年9月13日至9月15日在印度尼西亚巴厘岛举行的第八届艾滋病口腔健康和疾病世界研讨会上讨论的以下问题：（a）HIV感染如何影响上皮细胞信号传导？(b)HIV感染如何影响细胞因子和其他先天性抗菌因子的产生，（c）HIV感染中免疫细胞的粘膜分布和功能如何改变？(d)T细胞如何影响HIV（口腔）发病机制和癌症？(e)艾滋病毒感染如何导致对结核病感染的易感性？
A crucial aspect of mucosal HIV transmission is the interaction between HIV, the local environmental milieu and immune cells. The oral mucosa comprises many host cell types including epithelial cells, CD4 + T cells, dendritic cells and monocytes/macrophages, as well as a diverse microbiome predominantly comprising bacterial species. While the oral epithelium is one of the first sites exposed to HIV through oral-genital contact and nursing infants, it is largely thought to be resistant to HIV transmission via mechanisms that are still unclear. HIV-1 infection is also associated with predisposition to secondary infections, such as tuberculosis, and other diseases including cancer. This review addresses the following questions that were discussed at the 8th World Workshop on Oral Health and Disease in AIDS held in Bali, Indonesia, 13 September –15 September 2019: (a) How does HIV infection affect epithelial cell signalling? (b) How does HIV infection affect the production of cytokines and other innate antimicrobial factors, (c) How is the mucosal distribution and function of immune cells altered in HIV infection? (d) How do T cells affect HIV (oral) pathogenesis and cancer? (e) How does HIV infection lead to susceptibility to TB infections?
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影响因子：
6.7
作者：
Chevalier MF;Petitjean G;Dunyach-Rémy C;Didier C;Girard PM;Manea ME;Campa P;Meyer L;Rouzioux C;Lavigne JP;Barré-Sinoussi F;Scott-Algara D;Weiss L
通讯作者：
Weiss L
影响因子：
3.8
作者：
Ahmed, A.;Rakshit, S.;Vyakarnam, A.
通讯作者：
Vyakarnam, A.
影响因子：
5.4
作者：
Amelio, Patrizia;Portevin, Damien;Perreau, Matthieu
通讯作者：
Perreau, Matthieu
影响因子：
6.7
作者：
Chung, Charlotte Y.;Alden, Stephanie L.;Levine, Alan D.
通讯作者：
Levine, Alan D.
DOI：
10.1007/s10096-009-0786-5
发表时间：
2009-11-01
影响因子：
4.5
作者：
Goncalves, L. de Souza;Souto, R.;Colombo, A. P. V.
通讯作者：
Colombo, A. P. V.