Blood in the joint: effects of hemarthrosis on meniscus health and repair techniques.
Blood in the joint: effects of hemarthrosis on meniscus health and repair techniques.
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DOI：
10.1016/j.joca.2020.11.008
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发表时间：
2021-04
影响因子：
7
通讯作者：
McNulty AL
中科院分区：
文献类型：
--
作者：
Lyons LP;Weinberg JB;Wittstein JR;McNulty AL
半月板损伤是常见的，经常导致创伤后骨关节炎（PTOA）的发展。很多时候，半月板损伤与前交叉韧带（ACL）损伤同时发生，并导致血性关节积液。关节积血或关节内出血与关节组织变性有关。这篇综述文章的目的是了解血液诱导的关节损伤的病理生理学，血液对半月板组织的可能影响，以及对当前半月板修复技术的影响，这些技术涉及将血液衍生产品引入关节。在这篇综述中，我们阐述了血友病性关节病（HA）和骨关节炎（OA）关节损伤的病理生理学的相似性。尽管许多研究已经揭示了血液对软骨和滑膜的有害影响，但目前关于关节积血对半月板组织稳态、愈合和半月板损伤后PTOA发展的影响的知识存在空白。鉴于许多半月板修复技术使用血液和骨髓衍生的产品，因此必须了解这些因素对半月板组织和整个关节器官的影响，以制定改进的策略来促进半月板组织修复并预防PTOA的发展。
Injury to the meniscus is common and frequently leads to the development of post-traumatic osteoarthritis (PTOA). Many times meniscus injuries occur coincident with anterior cruciate ligament (ACL) injuries and lead to a bloody joint effusion. Hemarthrosis, or bleeding into the joint, has been implicated in degeneration of joint tissues. The goal of this review paper is to understand the pathophysiology of blood-induced joint damage, the possible effects of blood on meniscus tissue, and the implications for current meniscus repair techniques that involve the introduction of blood-derived products into the joint. In this review, we illustrate the similarities in the pathophysiology of joint damage due to hemophilic arthropathy (HA) and osteoarthritis (OA). Although numerous studies have revealed the harmful effects of blood on cartilage and synovium, there is currently a gap in knowledge regarding the effects of hemarthrosis on meniscus tissue homeostasis, healing, and the development of PTOA following meniscus injury. Given that many meniscus repair techniques utilize blood-derived and marrow-derived products, it is essential to understand the effects of these factors on meniscus tissue and the whole joint organ to develop improved strategies to promote meniscus tissue repair and prevent PTOA development.
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