Metabolic syndrome in women with and without interstitial cystitis/bladder pain syndrome
Metabolic syndrome in women with and without interstitial cystitis/bladder pain syndrome
复制标题
患有或不患有间质性膀胱炎/膀胱疼痛综合征的女性的代谢综合征
DOI：
10.1007/s00192-020-04605-w
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发表时间：
2020-11
影响因子：
1.8
通讯作者：
De-yi Luo
中科院分区：
文献类型：
--
作者：
Liao Peng;Xing-peng Di;Shi-xin He;Xiao Zeng;Hong Shen;Hui-Li Zhu;De-yi Luo
前言与假设本研究旨在比较间质性膀胱炎/膀胱痛综合征(IC/BPS)患者与非IC/BPS患者代谢综合征(METS)的发生率。方法采用病例对照研究方法，对2010年1月至2020年1月在西中国医院就诊的287例IC/BPS患者和287例非IC/BPS女性患者的代谢综合征指标进行评价。结果根据美国国家胆固醇教育计划成人治疗小组III推荐标准和国际糖尿病联合会标准，IC/BPS患者MET的分布显著高于对照组，分别为34.8%比17.8%(P<； 0.0001)和34.2%比20.9%(P= 0.0005)。在症状评分方面，IC/BPS组各方面评分均显著高于对照组(P<； 0.0001)。合并焦虑(P<； 0.0001)、失眠(P<； 0.0001)、高血压(P= 0.0001)和糖尿病(P= 0.017)的患者明显多于IC/BPS组。此外，研究结果还表明，IC/BPS患者的体重指数较高(P= 0.0001)，腰围较大(P= 0.0001)。血液检测显示IC/BPS患者的空腹血糖、血清胱抑素-C和甘油三酯水平显著升高。结论IC/BPS患者发生METS的频率相对较高。IC/BPS和METS的共同病理生理机制尚需进一步研究。
Introduction and hypothesisThe aim of this study was to compare the frequency of metabolic syndrome (MetS) in patients with and without interstitial cystitis/bladder pain syndrome (IC/BPS).MethodsThis case-control study evaluated the indicators of MetS in 287 females with IC/BPS and in 287 females without IC/BPS in West China Hospital between January 2010 and January 2020. Then, the number of voids per day, frequency of night urination, O’Leary-Sant Interstitial Cystitis Symptom/Problem Index, and visual analog scale were examined in the two groups.ResultsBased on both the National Cholesterol Education Program Adult Treatment Panel III recommendations and the International Diabetes Federation criteria, the distribution of MetS was statistically higher in patients with IC/BPS than in the control group, with 34.8% vs 17.8% (P< 0.0001) and 34.2% vs 20.9% (P= 0.0005), respectively. Regarding symptom scores, the IC/BPS group demonstrated significantly higher scores than the control group in all aspects (P< 0.0001). More patients with anxiety (P< 0.0001), insomnia (P< 0.0001), hypertension (P= 0.0001), and diabetes mellitus (P= 0.017) were observed in the IC/BPS group. Moreover, the findings indicated that patients with IC/BPS had a higher BMI (P= 0.0001) and larger waist circumference (P= 0.0001). Blood tests presented a significantly higher level of fasting glycemia, serum cystatin-C, and triglycerides in patients with IC/BPS. Furthermore, higher ORs for the occurrence of MetS among cases were observed, although this was not statistically significant.ConclusionsMetS frequency was relatively high in patients with IC/BPS. Further research is needed to understand the common pathophysiologic mechanism of IC/BPS and MetS.
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影响因子：
9.8
作者：
Y. Kim;J. Kim;Sun Mie Kim;Yunhee Choi;M. Jeon
通讯作者：
Y. Kim;J. Kim;Sun Mie Kim;Yunhee Choi;M. Jeon
影响因子：
23.4
作者：
Temml, Christian;Wehrberger, Clemens;Madersbacher, Stephan
通讯作者：
Madersbacher, Stephan
影响因子：
2.3
作者：
Jhang JF;Kuo HC
通讯作者：
Kuo HC
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.
DOI：
10.2147/dmso.s106221
发表时间：
2016
期刊：
Diabetes, metabolic syndrome and obesity : targets and therapy
影响因子：
--
作者：
de Oliveira MC;Varella LR;Angelo PH;Micussi MT
通讯作者：
Micussi MT