The Mediation and Moderation Effect Association among Physical Activity, Body-Fat Percentage, Blood Pressure, and Serum Lipids among Chinese Adults: Findings from the China Health and Nutrition Surveys in 2015.
The Mediation and Moderation Effect Association among Physical Activity, Body-Fat Percentage, Blood Pressure, and Serum Lipids among Chinese Adults: Findings from the China Health and Nutrition Surveys in 2015.
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中国成年人体力活动、体脂率、血压和血脂之间的中介和调节效应关联：2015年中国健康与营养调查的结果。
DOI：
10.3390/nu15143113
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发表时间：
2023-07-12
期刊：
影响因子：
5.9
通讯作者：
Zhang, Huadong
中科院分区：
文献类型：
--
作者：
Zou, Qinpei;Su, Chang;Du, Wenwen;Ouyang, Yifei;Wang, Huijun;Zhang, Bing;Luo, Shuquan;Tan, Tao;Chen, Yaokai;Zhong, Xiaoni;Zhang, Huadong
关键词：
体育活动（PA）是有益的，特别是对于心血管疾病的风险因素，因为久坐已成为一种生活习惯。体力活动与体脂率（BF%）、血压和血脂之间复杂关系的研究有限。本研究基于一项观察性研究，研究对象为居住在中国15个省份的成年人（18岁至18岁）。对2015年中国健康与营养调查（CHNS）中10148名成年人的数据进行分析。采用带协变量的简单中介效应模型评估血压和血脂之间的相关性，以BF%为中介。为了进一步分析PA与血压的关系，我们构建了带协变量的串联多中介模型，其中BF%为中介因子1，血脂为中介因子2。基于上述假设，采用带协变量的调节中介模型分析PA、BF%与血压的相关性；以BF%为调节因子，血脂为调节因子。在简单中介模型中，带因变量的模型为高密度脂蛋白胆固醇（HDL-C）或低密度脂蛋白胆固醇（LDL-C）；BF%发挥部分中介作用，贡献率分别为0.23和0.25。在串联多中介模型中，血脂作为第二中介发挥中介作用；但效果小于BF%。在有调节的中介模型中，血脂作为调节变量具有调节作用。HDL-C在“PA→BF%→收缩压/舒张压”中介模型的后一途径中起调节作用，LDL-C/TC在“PA→BF%→舒张压”的直接作用中起调节作用。综上所述，BF%在PA与血压的关系中起中介作用。HDL-C、LDL-C和TC在“PA→BF%→收缩压/舒张压”中介模型中更可能是调节变量。PA可以直接或间接地同时控制心血管疾病的危险因素。
Physical activity (PA) is of benefit and particularly important for cardiovascular disease risk factors as being sedentary becomes a lifestyle habit. Research into Chinese complex association among physical activity, body-fat percentage (BF%), blood pressure, and serum lipids is limited. The present study is based on an observational study among adults (>18 years old) residing in fifteen provinces in China. Data of 10,148 adult participants in the 2015 China Health and Nutrition Survey (CHNS) were analyzed. The simple mediation effect models with covariates were utilized to assess the association among PA and blood pressure or serum lipids, and BF% was played as a mediator. The serial multiple-mediator models with covariates were constructed to the further analysis of the relationship between PA and blood pressure, and BF% was the mediator 1 and blood lipids were the mediator 2. Based on the above hypothesis, the moderated mediation models with covariates were used to analyze the association among PA, BF%, and blood pressure; in addition, BF% was used as the mediator and blood lipids played as the moderator. In the simple mediation models, the model with a dependent variable was high-density lipoprotein cholesterol (HDL-C) or low-density lipoprotein cholesterol (LDL-C); BF% was played as the partly mediation effect and the proportion of contribution was 0.23 and 0.25, respectively. In the serial multiple-mediator models, blood lipids, as the second mediator, played the mediation effect; however, the effect was smaller than the BF%. In the moderated mediation model, blood lipids had the moderation effect as the moderator variable. HDL-C played a moderating role in the latter pathway of the “PA→BF%→SBP/DBP” mediation model, and LDL-C/TC played a moderating role in the direct effect of the “PA→BF%→DBP”. In conclusion, BF% played a mediating role in the relationship between PA and blood pressure. HDL-C, LDL-C, and TC were more likely to act as moderating variables in the mediation model “PA→BF%→SBP/DBP”. PA could directly and indirectly benefit to control the CVD risk factors simultaneously.
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