Socioeconomic status moderates age-related differences in the brain's functional network organization and anatomy across the adult lifespan.
Socioeconomic status moderates age-related differences in the brain's functional network organization and anatomy across the adult lifespan.
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DOI：
10.1073/pnas.1714021115
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发表时间：
2018-05-29
影响因子：
11.1
通讯作者：
Wig GS
中科院分区：
文献类型：
--
作者：
Chan MY;Na J;Agres PF;Savalia NK;Park DC;Wig GS
一个人的社会经济地位（SES）是其周围环境的一个中心特征，并已被证明与儿童时期大脑的发育和成熟有关。在这里，我们证明了一个人的目前（成人）SES涉及到他们的大脑功能和解剖结构在广泛的中年成年。在中年人（35-64岁）中，与SES较高的个体相比，SES较低的个体表现出组织化程度较低的功能性大脑网络和皮质厚度减少。这些关系不能完全用健康、人口统计学或认知的差异来解释。此外，儿童社会经济地位并不能解释社会经济地位与脑网络组织之间的关系。这些观察结果为环境和大脑之间的强大关系提供了支持，这种关系在中年人中很明显。一个人的环境与他们大脑的发育和成熟相互作用。一个人的环境的一个重要方面是他或她的社会经济地位（SES），估计获得物质资源和社会声望。以前对SES和大脑之间关系的描述主要集中在寿命的早期或晚期（即，童年，老年）。我们扩大这项工作，以研究SES和大脑之间的关系在广泛的人类成年期（20-89岁），包括个人从研究较少的中年范围。社会经济地位，由教育程度和职业社会经济特征定义，温和派以前报告的大脑的功能网络组织和全脑皮层结构的年龄相关的差异。在中年（35-64岁），较低的社会经济地位与减少静息态系统隔离（有效的功能网络组织的措施）。SES和年龄之间在脑解剖学方面存在类似但不太稳健的关系：SES较低与中年时皮质灰质厚度减少有关。相反，年轻人和老年人在大脑测量中没有表现出一致的SES相关差异。在控制了身心健康、认知能力和参与者人口统计学指标后，SES与大脑的关系仍然存在。关键是，一个人的童年社会经济地位不能说明他们目前的社会经济地位和功能网络组织之间的关系。这些研究结果提供了证据表明，SES与成年中年的大脑功能网络组织和解剖结构有关，并且较高的SES可能是对抗与年龄相关的大脑衰退的保护因素。
An individual’s socioeconomic status (SES) is a central feature of their environmental surroundings and has been shown to relate to the development and maturation of their brain in childhood. Here, we demonstrate that an individual’s present (adult) SES relates to their brain function and anatomy across a broad range of middle-age adulthood. In middle-aged adults (35–64 years), lower SES individuals exhibit less organized functional brain networks and reduced cortical thickness compared with higher SES individuals. These relationships cannot be fully explained by differences in health, demographics, or cognition. Additionally, childhood SES does not explain the relation between SES and brain network organization. These observations provide support for a powerful relationship between the environment and the brain that is evident in adult middle age. An individual’s environmental surroundings interact with the development and maturation of their brain. An important aspect of an individual’s environment is his or her socioeconomic status (SES), which estimates access to material resources and social prestige. Previous characterizations of the relation between SES and the brain have primarily focused on earlier or later epochs of the lifespan (i.e., childhood, older age). We broaden this work to examine the relationship between SES and the brain across a wide range of human adulthood (20–89 years), including individuals from the less studied middle-age range. SES, defined by education attainment and occupational socioeconomic characteristics, moderates previously reported age-related differences in the brain’s functional network organization and whole-brain cortical structure. Across middle age (35–64 years), lower SES is associated with reduced resting-state system segregation (a measure of effective functional network organization). A similar but less robust relationship exists between SES and age with respect to brain anatomy: Lower SES is associated with reduced cortical gray matter thickness in middle age. Conversely, younger and older adulthood do not exhibit consistent SES-related difference in the brain measures. The SES–brain relationships persist after controlling for measures of physical and mental health, cognitive ability, and participant demographics. Critically, an individual’s childhood SES cannot account for the relationship between their current SES and functional network organization. These findings provide evidence that SES relates to the brain’s functional network organization and anatomy across adult middle age, and that higher SES may be a protective factor against age-related brain decline.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
DOI：
10.1073/pnas.1415122111
发表时间：
2014-11-18
影响因子：
11.1
作者：
Chan, Micaela Y.;Park, Denise C.;Wig, Gagan S.
通讯作者：
Wig, Gagan S.
影响因子：
3.7
作者：
Baltes, PB;Lindenberger, U
通讯作者：
Lindenberger, U
影响因子：
4.1
作者：
Fjell, Anders M.;Walhovd, Kristine B.
通讯作者：
Walhovd, Kristine B.
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI